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Chemical Structure : VX-222
CAS No.: 1026785-59-0
Catalog No.: PC-45961Not For Human Use, Lab Use Only.
A potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $246.4 | In stock | |
| 50 mg | $792 | In stock |
Bulk size, bulk discount!
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A potent and selective, nonnucleoside inhibitor of HCV NS5B polymerase inhibitor with Kd of 17 nM; inhibits the 1b/Con1 HCV subgenomic replicon with EC50 of 17 nM, the M423I and A486S variants remaine susceptible to VX-222; exhibits non-competitive and selective inhibition in HCV NS5B of genotype 1a and 1b, with IC50 of 0.94 and 1.2 uM, respectively; displays fine pharmacokinetic profile in rats and dogs.
HCV Infection
Phase 2 Discontinued
| M.Wt | 445.6147 | |
| Formula | C25H35NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]- |
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1. Yi G, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):830-7.
2. Jiang M, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5456-65.
3. Di Bisceglie AM, et al. Eur J Gastroenterol Hepatol. 2014 Jul;26(7):761-73.
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