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Chemical Structure : WOBE-437
Catalog No.: PC-70227Not For Human Use, Lab Use Only.
WOBE-437 (WOBE437) is a potent, selective endocannabinoid uptake inhibitor with IC50 of 10 nM, with an outstanding 1,000-fold selectivity over FAAH.
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WOBE-437 (WOBE437) is a potent, selective endocannabinoid uptake inhibitor with IC50 of 10 nM, with an outstanding 1,000-fold selectivity over FAAH; exerts pronounced cannabinoid receptor-dependent anxiolytic, antiinflammatory, and analgesic effects in mice by increasing endocannabinoid levels; WOBE437 is orally bioavailable, significantly elevates AEA in the somatosensory cortex, inhibits analgesia in the hot plate test in a cannabinoid CB1 receptor-dependent manner, without inducing catalepsy or affecting locomotion.
| M.Wt | 359.51 | |
| Formula | C22H33NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chicca A, et al. Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E5006-E5015.
2. Reynoso-Moreno I, et al. Front Mol Neurosci. 2018 May 28;11:180.
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