Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Y08060
Catalog No.: PC-63245Not For Human Use, Lab Use Only.
Y08060 is a potent and selective BET inhibitor with Kd of 306 nM for BRD4 BD1, displays excellent selectivity for BET subfamily over other non-BET family with the exception of moderate inhibition of CBP/EP300.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Y08060 is a potent and selective BET inhibitor with Kd of 306 nM for BRD4 BD1, displays excellent selectivity for BET subfamily over other non-BET family with the exception of moderate inhibition of CBP/EP300; esuppresses cell growth, colony formation, and expression of androgen receptor (AR), AR regulated genes, and MYC in prostate cancer cell lines. such as C4-2B, LNCaP, and 22Rv1; demonstrates good PK profile with high oral bioavailability (61.54%).
| M.Wt | 471.322 | |
| Formula | C18H19BrN2O6S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Xiang Q, et al. ACS Med Chem Lett. 2018 Feb 13;9(3):262-267.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
