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Chemical Structure : YL0919
CAS No.: 1339058-04-6
Catalog No.: PC-42254Not For Human Use, Lab Use Only.
YL0919 (Hypidone hydrochloride) is an orally active, dual 5-HT1A agonist and selective serotonin reuptake inhibitor with Ki of 0.19 nM and IC50 of 1.78 nM, respectively.
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|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
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YL0919 (Hypidone hydrochloride) is an orally active, dual 5-HT1A agonist and selective serotonin reuptake inhibitor with Ki of 0.19 nM and IC50 of 1.78 nM, respectively.
YL0919 shows no affinity for dopamine receptors and others 5-HT receptors.
YL0919 inhibits forskolin-stimulated cAMP formation and 5-HT uptake in both rat cortical synaptosomes and recombinant cells.
YL0919 significantly reverses the depressive-like behaviors in chronically stressed rats.
| M.Wt | 334.8404 | |
| Formula | C18H23ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
2(1H)-Pyridinone, 1-[[4-hydroxy-1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1) |
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1. Chen HX, et al. PLoS One. 2013 Dec 18;8(12):e83271.
2. Zhang LM, et al. Br J Pharmacol. 2017 May;174(9):769-780.
3. Qin JJ, et al. Neurosci Lett. 2014 Oct 17;582:104-8.
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