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cis Ned-19

Chemical Structure : cis Ned-19

CAS No.: 1137264-00-6

cis Ned-19

Catalog No.: PC-62183Not For Human Use, Lab Use Only.

cis Ned-19 is the stereoisomer of trans Ned-19, a chemical probe for the Ca(2+)-releasing second messenger NAADP.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

cis Ned-19 is the stereoisomer of trans Ned-19, a chemical probe for the Ca(2+)-releasing second messenger NAADP; shows weaker potentcy than trans Ned-19, in regard to both inhibition of Ca2+ release (IC50=800 nM ) and [32P]NAADP binding (IC50=15 uM).

Physicochemical Properties

M.Wt 514.59
Formula C30H31FN4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

References

1. Naylor E, et al. Nat Chem Biol. 2009 Apr;5(4):220-6.

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