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Cat. No. Product Name CAS No. Information
PC-70041

ST-034307

133406-29-8

ST-034307 (ST 034307, ST034307) is a potent, selective adenylyl cyclase 1 (AC1) with IC50 of 2.3 uM; shows no activity against other AC isoforms; inhibits Ca2+-stimulated cAMP accumulation in HEK cells, also inhibits AC1 activity stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells; reduces pain responses in a mouse model of inflammatory pain.

PC-35246

AC5 inhibitor C90

AC5 inhibitor C90 is a novel potent, selective adenylyl cyclase type 5 (AC5) inhibitor with IC50 of 30 nM, >5-fold selectivity over AC2 and AC6 subtypes; exhibits enhanced AC5 inhibition efficacy and selectivity than PMC6 (IC50=0.15 μM), and 37 times lower than Vidarabine (IC50=1.11 uM); reducesd cAMP in response to forskolin in wild type mice by 42%, but no longer reduced cAMP in response to forskolin in mice with disruption of AC5, reduces myocardial infarct size even when administered after coronary artery reperfusion in vivo.
PC-62711

CB-6673567

379218-90-3 CB-6673567 is a potent, selective Adenylyl Cyclase 1 (AC1) inhibitor with IC50 of 77 uM, displays a 2- to 4-fold isoform selectivity over AC6; blocks the choline-induced cAMP increase in hippocampal neurons.
PC-62710

CB-7921220

115453-99-1 CB-7921220 is a potent, selective Adenylyl Cyclase 1 (AC1) inhibitor.
PC-62254

NKH 477 hydrochloride

138605-00-2 NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase; increases cAMP accumulation in HEK293 cells stably overexpressing type V more than forskolin; A PKA activator.

Heart Failure

Approveed

PC-60892

KH7

330676-02-3 A potent, specific soluble adenylyl cyclase (sAC) inhibitor that inhibits Mn2+-dependent sAC with IC50 of 2.7 uM; inhibits physiologically stimulated sAC with similar potency with IC50 of 8.0 uM, completely blocks the capacitation-induced rise in cAMP in wild-type sperm at 10 uM, inhibits in vitro fertilization.
PC-60891

LRE1

1424605-11-7 A novel potent, specific and allosteric soluble adenylyl cyclase (sAC) inhibitor with IC50 of 3.3 uM in RF-MSS assays; does not inhibit other transmembrane adenylyl cyclases (tmACs) indluding tmACs I, II, V, VIII and IX at 50 uM; binds to the bicarbonate activator binding site and inhibited sAC via a unique allosteric mechanism; inhibits cAMP accumulation in 4-4 cells with an IC50 of 11 uM, and is non-toxic and does not uncouple mitochondria.

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