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Cat. No. Product Name Information
PC-20086

BAY1128688

AKR1C3 inhibitor

BAY1128688 is a potent, steroidal aldo-keto reductase 1C3 (AKR1C3) inhibitor with potential for endometriosis.
PC-45580

Caficrestat

AT-001 (Caficrestat) is a highly potent, selective inhibitor of aldose reductase enzymatic activity with IC50 of 28.9 pM.
PC-45922

Epalrestat

A noncompetitive and reversible aldose reductase inhibitor with IC50 of 10 nM and 26 nM for purified aldose reductase from rat lens and human placenta, respectively.
PC-20625

Imirestat

Aldose reductase inhibitor

Imirestat (AL-1576) is a potent aldose reductase inhibitor with IC50 of 8.5 nM for rat lens aldose reductase, with similar IC50 value for the human placental enzyme, shows high affinity for AKR1A1 and AKR1B1 with Ki of 47 and 46 nM respectively.
PC-38679

Govorestat

Aldose Reductase inhibitor

Govorestat (AT-007) is a potent, selective, CNS-penetrant aldose reductase (aldehyde reductase) inhibitor with IC50 of 0.1 nM, reduces toxic galactitol levels and prevents galactosemia disease complications in vivo.
PC-62883

MK-204

MK-204 is a potent, selective AKR1B10 inhibitor with IC50 of 80 nM, shows high selective (270-fold) over AKR1B1.
PC-62882

IDD388

IDD388 is a potent aldose reductase (ALR2 or AKR1B1) inhibitor with IC50 of 0.4 uM, shows weak inhibition for AKR1B10 (IC50=4.4 uM)..
PC-61992

Fidarestat

Fidarestat (SNK860) is a potent aldose reductase inhibitor, improves motor nerve conduction velocity (MNCV) and metabolic abnormalities in sciatic nerve were investigated in acute STZ-induced diabetic rats..

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