| Cat. No. |
Product Name |
Information |
| PC-45933 |
N-desmethyl Enzalutamide
Enzalutamide metabolite
|
N-desmethyl Enzalutamide is a major metabolite of Enzalutamide (MDV3100) which is an androgen-receptor (AR) antagonist for treatment of prostate cancer. |
| PC-42794 |
MK-0773
SARM
|
MK-0773 (PF-05314882) is a potent, selective androgen receptor modulator (SARM) with binding IC50 of 6.6 nM. |
| PC-45113 |
Darolutamide
AR antagonist
|
Darolutamide (ODM-201, BAY-1841788) is a potent wt/mutant androgen receptor (AR) inhibitor with Ki of 11 nM. |
| PC-42075 |
GSK2881078
SARM
|
GSK2881078 potent and selective androgen receptor modulator (SARM), act as partial AR agonist and induces AR-mediated transcriptional activation in PC3(AR)2 cells with EC50 of 3.99 nM. |
| PC-45421 |
GLPG0492
SARM
|
GLPG0492 (GLPG-0492) is an orally active, non-steroidal selective androgen receptor modulator (SARM) with in vitro potency of 13 nM. |
| PC-42652 |
RU 58841
AR inhibitor
|
RU 58841 nonsteroidal, specific androgen receptor inhibitor, show potential for the topical treatment of androgen-dependent skin disorders such as acne, androgenetic alopecia and hirsutism. |
| PC-27015 |
KCI838PME
AR-ELK1 inhibitor
|
KCI838PME is a soluble 3’phosphate monoester prodrug of KCI838, AR-dependent growth by selectively binding to AR and blocking its association with ELK1, blocks AR binding to ELK1, inhibits enzalutamide-resistant patient-derived PCa tumor xenograft. |
| PC-27014 |
KCI838
AR-ELK1 inhibitor
|
KCI838 is a specific small molecule inhibitor of androgen receptor (AR)-dependent growth by selectively binding to AR and blocking its association with ELK1, blocks AR binding to ELK1. |
| PC-26992 |
AR-NTD antagonist K53
AR-NTD inhibitor
|
AR-NTD antagonist K53 is a potent, selective antagonist of androgen receptor N-terminal domain (AR-NTD) with SPR KD of 25.1 uM (AR-NTD-AF1 fragment), exhibits potent anti-proliferative activity in enzalutamide-resistant prostate cancer cells. |
| PC-26659 |
T878A-mutant AR inhibitor S-94
T878A-mutant AR antagonist
|
T878A-mutant AR inhibitor S-94 is a selective androgen receptor T878A-mutant androgen receptor (AR) antagonist, inhibits AR transcriptional activity (IC50=0.38 μM) and suppresses cell proliferation (IC50=10.32 μM) in LNCaP cells harboring the T878A-mutant AR. |
| PC-25059 |
AZD3514
AR inhibitor
|
AZD3514 is an orally bioavailable small-molecule androgen receptor downregulator with pIC50 of 5.75, inhibits androgen-dependent and -independent AR signaling. |
| PC-25024 |
Dimethylcurcumin
AR inhibitor
|
Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer that effectively suppresses castration resistant prostate cancer cell proliferation and invasion. |
