| Cat. No. |
Product Name |
Information |
| PC-62007 |
LSN 3213128
AICARFT inhibitor
|
LSN 3213128 is a novel potent, selective and orally-bioavailable antifolate with potent and specific inhibitory activity for AICARFT. |
| PC-60506 |
Arfolitixorin
Antifolate
|
Arfolitixorin is a novel antifolate modulator compound, is a substrate for methylenetetrahydrofolate reductase to generate 5-methyltetrahydrofolate. |
| PC-70211 |
LY345899
MTHFD1/2 inhibitor
|
LY345899 (LY 345899) is a novel potent, cytoplasmic and mitochondrial methylenetetrahydrofolate dehydrogenase MTHFD1 and MTHFD2 inhibitor with IC50 of 96 nM and 663 nM, respectively. |
| PC-42590 |
Pralatrexate
DHFR inhibitor, Antifolate
|
Pralatrexate is a potent dihydrofolate reductasean (DHFR) inhibitor with Ki of 13.4 pM, is an antifolate and has antitumor activities. |
| PC-42556 |
Trimetrexate
DHFR inhibitor
|
Trimetrexate (CI-898, NSC249008) is a quinazoline derivative and antifolate agent that fuctions as a dihydrofolate reductase (DHFR) inhibitor. |
| PC-42710 |
Pemetrexed disodium
Antifolate
|
Pemetrexed disodium is a classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively. |
| PC-42709 |
Pemetrexed
Antifolate
|
Pemetrexed (LY231514) is a classical multitargeted antifolate that inhibits multiple folate-requiring enzymes TS/DHFR/GARFT with Ki of 1.3/7.2/65 nM respectively. |
| PC-45206 |
Levomefolate calcium
|
Levomefolate calcium is a synthetic calcium salt of L-5-methyltetrahydrofolate and an orally active and brain-penetrant folate supplement. |
| PC-26410 |
Methotrexate
Antifolate
|
Methotrexate is antifolate agent and dihydrofolate reductase (DHFR) inhibitor. |
| PC-26409 |
Lometrexol
GARFT inhibitor, SHMT inhibitor
|
Lometrexol (DDATHF) is an antipurine antifolate and inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), also inhibits serine hydroxymethyltransferase (SHMT) with ITC KD of 2 uM. |
| PC-26408 |
Nolatrexed
Antifolate
|
Nolatrexed (AG337) is an orally active antifolate agent and thymidylate synthase (TS) inhibitor. |
| PC-26406 |
MTHFD2 inhibitor 31
MTHFD2 inhibitor
|
MTHFD2 inhibitor 31 is a potent, highly selective MTHFD2 inhibitor with IC50 of 38 nM, >180-fold selective over MTHFD1 (IC50=7440 nM). |
