| Cat. No. |
Product Name |
Information |
| PC-70096 |
GSK-7975A
CRAC channel blocker
|
GSK-7975A (GSK7975A) is a selective CRAC channel blocker that inhibits store-operated Ca(2+) entry (SOCE) with IC50 of 3.4 uM. |
| PC-60006 |
A-1048400
Calcium channel inhibitor
|
A-1048400 is a potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively. |
| PC-45686 |
ABT-639
T-type calcium channel inhibitor
|
ABT-639 is a novel, peripherally acting, selective T-type calcium channel blocker, blocks recombinant human Cav 3.2 in a voltage-dependent fashion (IC50=2 uM). |
| PC-45854 |
NNC 55-0396
T-type calcium channel inhibitor
|
NNC 55-0396 is a potent and selective T-type calcium channel antagonist that blocks recombinant alpha(1)G T-type channels in human embryonic kidney 293 cellswith IC50 of 7 uM. |
| PC-42314 |
MK-8998
T-type calcium channel inhibitor
|
MK-8998 (Suvecaltamide, CX-8998) is a potent and selective antagonist of the T-type calcium channel for the treatment of schizophrenia. |
| PC-22153 |
TTA-A2
T-type calcium channel inhibitor
|
TTA-A2 is a potent, selective, state-dependent T-type calcium channel antagonist with IC50 of 89 nM and 4100 nM in voltage clamp assays with -80-mV and -100-mV holding membrane potentials in HEK 293 cells heterologously expressing human CaV3.1, respectively. |
| PC-22078 |
MRS1845
SOCE channel inhibitor, Orai1 inhibitor
|
MRS1845 is a selective store-operated Ca2+ channel (SOC) Orai1 inhibitor, inhibits SOC channel-dependent elevations of calcium with IC50 of 1.7 uM in HL-60 cells. |
| PC-21849 |
TTA-Q6
T-type Ca2+ channel inhibitor
|
TTA-Q6 is a potent, selective T-type Ca2+ channel antagonist with IC50 of 14 nM and 590 nM in FLIPR depolarized assaay and FLIPR hyperpolarized assay, respectively. |
| PC-21384 |
CBD3063
CaV2.2 inhibitor
|
CBD3063 is a selective, first-in-class inhibitor of Cav2.2-CRMP2 (ollapsin response mediator protein 2) interaction, suppresses surface trafficking of Cav2.2, and N-type (Cav2.2) calcium currents. |
| PC-21371 |
S107
RyR2 stabilizer
|
S107 (RyR2 stabilizer) is a specific stabilizing cmpound of Ca2+ release channel ryanodine receptor 2 (RyR2), enhances calstabin2 binding and inhibits Ca2+ leak from mutant RyR2 channels. |
| PC-21312 |
TMDJ-035
RyR2 inhibitor
|
TMDJ-035 is the first highly potent and selective ryanodine receptor 2 (RyR2) inhibitor with EC50 of 13 nM, shows no effect on RyR1 and RyR3. |
| PC-20690 |
Ebselen
VDCC blocker
|
Ebselen (CCG-39161, PI-1005) is a potent voltage-dependent calcium channel (VDCC) blocker, also potently inhibits SARS CoV-2 Mpro with IC50 of 0.67 μM. |
