| Cat. No. |
Product Name |
Information |
| PC-62009 |
Z-944
T-type calcium channel inhibitor
|
Z-944 (Ulixacaltamide) is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels. |
| PC-62008 |
ACT-709478
T-type calcium channel inhibitor
|
Apinocaltamide (ACT-709478) is a potent, selective, orally-bioavailable, brain penetrant T-type calcium channel blocker with IC50 of 6.4, 18, and 7.5 nM for Cav3.1, Cav3.2, and Cav3.3 channels respectively. |
| PC-61847 |
Pregabalin
VDCC inhibitor
|
Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs). |
| PC-61833 |
Imagabalin
VDCC inhibitor
|
Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2. |
| PC-61832 |
Atagabalin
VDCC inhibitor
|
Atagabalin (PD 0200390) is a novel ligand of the voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) for treatment for insomnia. |
| PC-61779 |
SERCA2a activator A
SERCA2a activator
|
SERCA2a activator A is a novel sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a) activator that activates the Ca2+-dependent ATPase activity of cardiac SR vesicles but not that of skeletal muscle SR vesicles that lack of phospholamban (PLN). |
| PC-61012 |
DS16570511
MICU1 inhibitor
|
DS16570511 is a cell-permeable inhibitor of the mitochondrial calcium uniporter (MCU) that inhibits serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 uM. |
| PC-60979 |
AMG1
CRAC channel inhibitor
|
AMG1 is a specific CRAC channel inhibitor that blocks function of effector but not regulatory T cells in vitro and attenuates the pogression and severity of EAE in vivo. |
| PC-60883 |
Thapsigargin
SERCA inhibitor
|
Thapsigargin (G202) is a potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells. |
| PC-60679 |
TROX-1
Cav2 channels inhibitor
|
TROX-1 is a potent, state-dependent blocker of Cav2 channels that preferentially inhibits potassium-triggered calcium influx through recombinant Cav2.2 under depolarized conditions with IC50 of 0.27 uM, compared with hyperpolarized conditions (IC50>20 uM). |
| PC-70096 |
GSK-7975A
CRAC channel blocker
|
GSK-7975A (GSK7975A) is a selective CRAC channel blocker that inhibits store-operated Ca(2+) entry (SOCE) with IC50 of 3.4 uM. |
| PC-60006 |
A-1048400
Calcium channel inhibitor
|
A-1048400 is a potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively. |
