| Cat. No. |
Product Name |
Information |
| PC-24910 |
XIAP-CASP7 inhibitor 643943
Caspase 7 activator
|
XIAP-CASP7 inhibitor 643943 is a specific reversible XIAP-caspase 7 (CASP7) PPI inhibitor, binds to CASP7 Cys246 in an allosteric site, causes dissociation of XIAP to activate CASP7 and induces CASP7-mediated apoptosis. |
| PC-24253 |
Z-VAD-FMK
Caspase inhibitor
|
Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-known small molecule pan-caspase inhibitor and ICE-like protease inhibitor. |
| PC-24251 |
z-LEHD-FMK
Caspase-9 inhibitor
|
z-LEHD-FMK is a selective and irreversible inhibitor of Caspase-9, protects against lethal reperfusion injury and attenuates apoptosis, exhibits the neuroprotective effect in rat model of spinal cord trauma. |
| PC-24250 |
Ac-FLTD-CMK
Caspase-1/4/5 inhibitor
|
Ac-FLTD-CMK is a gasdermin D (GSDMD)-derived inhibitor and specific inflammatory caspases inhibitor for caspases-1 (IC50=46.7 nM), caspases-4 (IC50=1.49 μM), caspases-5 (IC50=329 nM), does not inhibit apoptotic caspases such as caspase-3. |
| PC-24249 |
Ac-LESD-CMK
Caspase-8 inhibitor
|
Ac-LESD-CMK is a potent, selective inhibitor of caspase-8 with IC50 of 50 nM, inhibits homolog caspase-10 with IC50 of 520 nM. |
| PC-24248 |
z-IETD-FMK
Caspase-8 inhibitor
|
Z-IETD-FMK (zIETD-FMK, Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor with IC50 of 350 nM. |
| PC-24054 |
ORF9b homodimerization inhibitor Y600
ORF9b inhibitor
|
ORF9b homodimerization inhibitor Y600 is a small molecule inhibitor of ORF9b homodimerization, inhibits ORF9b-ORF9b homotypic interaction, inhibits activation of caspase-1 in A549.ORF9b and THP-1.ORF9b cells with IC50 of 1 and 4 nM respectively. |
| PC-24053 |
ORF9b homodimerization inhibitor EN300
ORF9b inhibitor
|
ORF9b homodimerization inhibitor EN300 is a small molecule inhibitor of ORF9b homodimerization, inhibits ORF9b-ORF9b homotypic interaction, inhibits activation of caspase-1 in A549.ORF9b and THP-1.ORF9b cells with IC50 of 0.85 and 17 nM respectively. |
| PC-23805 |
FLIPinBγ
c-FLIPL inhibitor
|
FLIPinBγ is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death. |
| PC-23804 |
FLIPinB
c-FLIPL inhibitor
|
FLIPinB is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death. |
| PC-22972 |
Pralnacasan
Caspase-1 inhibitor
|
Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active Caspase-1 (interleukin-1β converting enzyme, ICE) inhibitor with Ki of 1.4 nM, inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. |
| PC-22971 |
CIB-1476
pro-caspase-1 inhibitor
|
CIB-1476 is an irreversible covalent inhibitor of pro-caspase-1 with IC50 of 0.65 uM, covalently targets pro-caspase-1 Cys285 and Cys397, inhibits NLRP3 inflammasome activation. |
