| Cat. No. |
Product Name |
Information |
| PC-63201 |
PNR-7-02
DNA Polη inhibitor
|
PNR-7-02 (PNR-07-02) is a specific inhibitor of human DNA Polymerase eta (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols. |
| PC-43056 |
BMH-21
RNA Pol I inhibitor
|
BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription. |
| PC-42973 |
Cycloheximide
Protein synthesis inhibitor
|
Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. |
| PC-62219 |
CX-3543
RNA Pol I inhibitor
|
CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting RNA Pol I transcription and inducing apoptosis in cancer cells. |
| PC-61350 |
Plicamycin
Sp1 inhibitor
|
Plicamycin (Mithramycin A, PA 144, NSC 24559) is a tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA, inhibits specificity protein 1 (Sp1) transcription factor. |
| PC-61229 |
ML-60218
RNA Pol III inhibitor
|
ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively. |
| PC-70241 |
Saframycin A
|
Saframycin A is a heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro. |
| PC-70029 |
Minnelide
RNA polymerase II inhibitor
|
Minnelide is a water-soluble prodrug of triptolide, an inhibitor of RNA polymerase II-mediated transcription, also is a selective inhibitor of CIC::DUX4 sarcoma (CDS). |
| PC-45353 |
Bleomycin sulfate
|
An anticancer agent that acts by induction of DNA strand breaks. |
| PC-45751 |
COH29
Ribonucleotide reductase inhibitor
|
COH29 is a small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM. |
| PC-42295 |
Beaucage reagent
|
A potent DNA cleavage agent. |
| PC-45350 |
Actinomycin D
Transcription inhibitor
|
Actinomycin D is a chemotherapy agent that has the ability to inhibit transcription, binds to DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase, inhibits DNA repair with IC50 of 0.42 uM. |
