| Cat. No. |
Product Name |
Information |
| PC-61927 |
(E)-Mirin
|
Mirin is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits MRN-mediated ATM activation (inhibition of H2AX phosphorylation) with IC50 of 66 uM. |
| PC-61926 |
PFM01
MRE11 inhibitor
|
PFM01 (SML1735) is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM. |
| PC-61925 |
PFM39
MRE11 inhibitor
|
PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, inhibits HR without significantly increasing NHEJ.. |
| PC-61924 |
6-Hydroxy-DOPA
RAD52 inhibitor
|
6-Hydroxy-DOPA (6-OH-DOPA) is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM. |
| PC-61922 |
NP-004255
RAD52 inhibitor
|
NP-004255 (NP004255, Corilagin) is a small molecule binds specifically to DNA repair protein RAD52 and disrupts the RAD52-ssDNA interaction, inhibits ssDNA binding with IC50 of 1.5 uM. |
| PC-61921 |
NSC 19630
WRN helicase inhibitor
|
NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM. |
| PC-61920 |
NSC 617145
WRN inhibitor
|
NSC 617145 is a novel small-molecule, selective inhibitor of WRN helicase with IC50 of 230 nM. |
| PC-61900 |
Rev1-IN-5
Rev1 inhibitor
|
Rev1-IN-5 is a small molecule inhibitor of the C-terminal domain of Rev1 and the Rev1-interacting region protein-protein interaction (Rev1-CT/RIR PPI) with IC50 of 2.5 uM. |
| PC-61067 |
BAY-707
MTH1 inhibitor
|
BAY-707 is a highly potent, selective and substrate-competitive inhibitor of MTH1 (NUDT1) with IC50 of 2.3 nM. |
| PC-42079 |
HUHS-015
PCA-1/ALKBH3 inhibitor
|
HUHS-015 (HUHS015) is a potent, orally active prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with IC50 of 0.67 uM. |
| PC-43226 |
TH-588
MTH1 inhibitor
|
TH-588 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 5 nM. |
| PC-45104 |
TH-287
MTH1 inhibitor
|
TH-287 is a potent and selective inhibitor of MTH1 (NUDT1) protein with IC50 of 0.8 nM. |
