| Cat. No. |
Product Name |
Information |
| PC-35243 |
OP-1074
|
OP-1074 (OP1074) is a potent, selective ER degrader (SERD), shows specific antiestrogenic activity for both ERα and ERβ, inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC50 of 1.6 and 3.2 nM, respectively. |
| PC-63334 |
GDC-0927 R-form
|
GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.. |
| PC-63333 |
GDC-0927 racemate
|
GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.. |
| PC-43264 |
GDC-0810
|
GDC-0810 (ARN-810, Brilanestrant) is a non-steroidal, orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM (ER-α degradation), binds to ERα and ERβ with with Ki of 3.8 and 3.7 nM, respectively. |
| PC-43234 |
BHPI
|
BHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells. |
| PC-43041 |
Diarylpropionitrile
|
Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand, demonstrates the neuroprotective effects against 10 0M Aβ1-42-induced oxidative stress and inflammation in primary rat cortical cell culture. |
| PC-42344 |
WAY-200070
|
WAY-200070 is a potent, highly selective ERβ agonist with IC50 of 3 nM, displays 68-fold selectivity over ERα (IC50=260 nM). |
| PC-70134 |
4-Hydroxytamoxifen
|
A selective estrogen receptor modulator (SERM) and the major active metabolite of tamoxifen. |
| PC-60267 |
PHTPP
|
A potent, selective antagonist of estrogen ERβ receptor. |
| PC-60204 |
Diptoindonesin G
|
A natural compound, novel chemical probe reciprocally stabilizes ERβ and destabilizes ERα in breast cancer cells. |
