| Cat. No. |
Product Name |
Information |
| PC-24541 |
Bazedoxifene
SERM
|
Bazedoxifene (TSE-424, WAY-140424) is a potent, orally bioavailable, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM) with IC50 of 23 nM and 99 nM for ERα and ERβ, respectively. |
| PC-24538 |
Estradiol
Steroid hormone
|
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone, Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation, Estradiol raises estrogen levels to reduce symptoms of menopause by improving vaginal health, reducing bone loss, and helping regulate body temperature. |
| PC-23654 |
EGX358
ERβ agonist
|
EGX358 (ISP358-2) is a potent, highly selective estrogen receptor-beta (ERβ) agonist with EC50 of 27 nM, 750-fold selectivity for ERβ over ERα. |
| PC-23616 |
Toremifene
SERM, Filovirus inhibitor
|
Toremifene (Z-Toremifene, NK 622 free base) is a selective estrogen receptor modulator (SERM), inhibits ebolavirus (EBOV) entry after internalization, shows potent antiviral activity in HepG2 cell lines with IC50 of 25.5 nM. |
| PC-23562 |
VPC-260724
ER-AF2 inhibitor
|
VPC-260724 is a specific small molecule inhibitor of estrogen receptor-activation function 2 (ER-AF2) with IC50 of 5.7 uM for inhibition of ER transcription in T47D-KBluc cells. |
| PC-23322 |
SR-16234
SERM
|
SR-16234 (TAS-108) is a selective estrogen receptor modulator (SERM), blocks both the N-terminal AF-1 and C-terminal AF-2 transactivation functions. |
| PC-22707 |
27-hydroxycholesterol
SERM
|
27-Hydroxycholesterol (27-OHC, 27HC) is a selective estrogen receptor (ER) modulator and an agonist of the liver X receptor (LXR), regulates both gene transcription and cell proliferation in cellular models of breast cancer. |
| PC-22504 |
T6I-29-1A
SERM
|
T6I-29-1A is the active enantiomer of T6I-29, which is a novel isoquinoline-based selective estrogen receptor modulator (SERM), interacts with Y537S ERα ligand binding domain (LBD), exhibits anti-proliferative activities. |
| PC-22503 |
T6I-29
SERM
|
T6I-29 is a novel isoquinoline-based selective estrogen receptor modulator (SERM), interacts with Y537S ERα ligand binding domain (LBD), exhibits anti-proliferative activities, downregulates target genes, and elicits anti-tumoral activities. |
| PC-21730 |
ERB-041
ERβ agonist
|
Prinaberel (ERB-041) is a potent, selective estrogen receptor beta (ERβ) agonist with IC50 of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. |
| PC-20995 |
X15695
ERα degrader
|
X15695 is a potent, selective and orally active estrogen receptor alpha (ERα) degrader, destabilizes ERα and stabilizes p53, inhibits ER+ breast cancer cell growth. |
| PC-20524 |
GNE-149
ER degrader
|
GNE-149 (GNE149) is a potent, full estrogen receptor alpha (ERα) antagonist and degrader with IC50 of 0.053 nM (MCF7, ERα degradation). |
