| Cat. No. |
Product Name |
Information |
| PC-42924 |
INT-747
FXR agonist
|
INT-747 (Obeticholic acid, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective FXR agonist (EC50=99 nM). |
| PC-45904 |
WAY-362450
FXR agonist
|
A highly potent, selective, and orally active agonist of FXR with EC50 of 4 nM. |
| PC-22169 |
F44-A13
FXR antagonist
|
F44-A13 is a highly selective farnesoid X receptor (FXR) antagonist with IC50 of 1.1 uM, with high selectivity over eleven other nuclear receptors. |
| PC-21879 |
ID166
FXR agonist
|
ID119031166 (ID166) is a novel potent, selective FXR agonist with EC50 of 3 nM and 5 nM in TR-FRET FXR co-activator assay and FXR reporter assay, respectively. |
| PC-20980 |
HPG1860
FXR agonist
|
HPG1860 is a potent, selective, nonbile acid full FXR agonist with EC50 of 5 nM and 18 nM in FR-FRET and luciferase assays, respectively. |
| PC-20979 |
MET409
FXR agonist
|
MET409 (MET-409) is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 16 nM (human FXR). |
| PC-20976 |
BMS-986318
FXR agonist
|
BMS-986318 is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 53 nM in FXR Gal4 luciferase reporter assays. |
| PC-20485 |
BAR502
Dual FXR/GPBAR1 agonist
|
BAR502 (NorECDCOH) is a potent, selective, dual farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligand (agonist) with EC50 of 2.0 and 0.4 uM, respectively. |
| PC-20484 |
PDL103
Dual FXR/GPBAR1 antagonist
|
PDL103 is a potent, dual FXR/GPBAR1 antagonist with IC50 of 10 and 19 uM, respectively. |
| PC-47028 |
BMS-986339
FXR agonist
|
BMS-986339 is a potent, selective farnesoid X receptor (FXR) agonist with EC50 of 34 nM (hFXR-Gal4), demonstrates differential induction of Fgf15 in the liver and ileum by FXR agonists in vivo. |
