| Cat. No. |
Product Name |
Information |
| PC-49182 |
GW559090
VLA-4 inhibitor
|
GW559090 is a potent, selective, competitive and high-affinity α4β1 integrin (VLA-4) antagonist with Kd of 0.19/1.04 nM for huamn/rat α4β1, respectively. |
| PC-38811 |
7HP349
LFA-1 activator
|
Alintegimod (7HP349) is a small molecule activator of the integrins αLβ2 (LFA-1) and α4β1 (VLA-4). 7HP349 directly activates integrin cell adhesion receptors crucial for the generation of an immune response. |
| PC-73406 |
Bexotegrast
ανβ6 integrin inhibitor
|
Bexotegrast (PLN-74809) is a potent, non-steroidal inhibitor of ανβ6 integrin with anti-inflammatory effect. |
| PC-73352 |
C67399
TLN1-integrin β1 inhibitor
|
C67399 is a small molecule that blocks the integrin β1 binding site of TLN1, reduces the malignant behaviours of TNBC in vitro (MDA-MB-231 cell, IC50=2.0 uM). |
| PC-72987 |
ADH-503
CD11b agonist
|
ADH-503 (GB1275, Leukadherin-1 choline) is a small-molecule allosteric agonist of CD11b that can render tumors more sensitive to checkpoint blockade. |
| PC-72429 |
AXT107
VEGFR2-β3 inhibitor
|
AXT107 (Gersizangitide) is a mimetic peptide derived from collagen IV, binds integrins αvβ3 and α5β1 (Kd=1.29 and 2.21 nM), disrupts VEGFR2-β3 complex formation. |
| PC-35693 |
SC-68448
Integrin αvβ3 inhibitor
|
SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3. |
| PC-35657 |
AJM300
|
AJM300 (Carotegrast methyl, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis.. |
| PC-35165 |
ALG1001
|
ALG1001 (Risuteganib, ALG-1001) is a first-in-class, RGD class oligopeptide that inhibits integrin receptors (αvβ3, αvβ5, and α5β1) associated with angiogenesis. |
| PC-62157 |
LLP2A
α4β1 integrin inhibitor
|
LLP2A is a high-affinity, selective peptidomimetic ligand of α4β1 integrin with IC50 of 2 pM. |
| PC-62001 |
MK-0429
αvβ3 integrin inhibitor
|
MK-0429 is a potent, selective, orally-active nonpeptide αvβ3 integrin inhibitor with IC50 of 0.08 nM in SPAV3 assay. |
| PC-61300 |
BIO-5192
|
BIO-5192 is a potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM. |
