| Cat. No. |
Product Name |
Information |
| PC-24170 |
Plodicitinib
JAK3/TEC kinase inhibitor
|
Plodicitinib is a highly potent, dual inhibitor of JAK3 kinase and BTK kinase with IC50 of 0.3 nM and 2.4 nM, respectively, suppresses T- and B-cell activation and differentiation by inhibiting JAK3 and Tec family kinases, including BTK and ITK. |
| PC-24155 |
Milpecitinib
JAK inhibitor
|
Milpecitinib is potent, selective Janus tyrosine kinase (JAK) inhibitor. |
| PC-24147 |
Lirucitinib
JAK1 inhibitor
|
Lirucitinib (GGW101, GGW 101) is a potent, selective JAK inhibitor. |
| PC-22993 |
Pacritinib
JAK2/FLT3 inhibitor
|
Pacritinib (SB1518) is a potent, selective JAK2/FLT3 inhibitor with IC50 of 23 and 19 nM for JAK2(WT) and JAK2(V617F), and IC50 of 22 nM for FLT3. |
| PC-22718 |
Coumermycin A1
JAK2 agonist
|
Coumermycin A1 (C-A1) is a small molecule JAK2 agonist that induces dimerization and activation of JAK2, also inhibits DNA Gyrase and cell division in bacteria. |
| PC-22634 |
CS12192
JAK//TBK1 inhibitor
|
CS12192 is a potent, selective JAK3/JAK1/TBK1 inhibitor with IC50 of 11/105/162 nM, respectively. |
| PC-22617 |
Oclacitinib
JAK inhibitor
|
Oclacitinib (PF-03394197) is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
| PC-22495 |
MS-1020
JAK3 inhibitor
|
MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner. |
| PC-22404 |
GLPG3667
TYK2 inhibitor
|
Cadefrecitinib (GLPG3667) is a potent, reversible and selective, ATP-competitive TYK2 inhibitor with IC50 of 2.3 nM. |
| PC-22378 |
TYK2 inhibitor X
TYK2 inhibitor
|
TYK2 inhibitor X is a potent, selective and blood-brain barrier (BBB) permeable TYK2 inhibitor. |
| PC-22203 |
JAK3 inhibitor MJ04
JAK3 inhibitor
|
JAK3 inhibitor MJ04 is a potent and highly selective, ATP competitive JAK3 inhibitor with IC50 of 2.03 nM (2.5 µM ATP), >90-fold selectivity over JAK1 and JAK2, shows potential hair growth promoter activity. |
| PC-22202 |
JAK3 inhibitor RB1
JAK3 inhibitor
|
JAK3 inhibitor RB1 is a potent, selective and irreversible JAK3 inhibitor with IC50 of 40 nM, without inhibiting JAK1, JAK2 or TYK2 (IC50>5000 nM). |
