| Cat. No. |
Product Name |
Information |
| PC-24148 |
Lirucitinib hydrochloride
JAK inhibitor
|
Lirucitinib hydrochloride is a potent, selective JAK inhibitor. |
| PC-24147 |
Lirucitinib
JAK inhibitor
|
Lirucitinib is a potent, selective JAK inhibitor. |
| PC-23784 |
Dual JAK3-TEC kinase inhibitor ZZB
JAK3/TEC kinase inhibitor
|
Dual JAK3-TEC kinase inhibitor ZZB is a potent, selective, covalent dual JAK3/TEC family kinases inhibitor with IC50 of 0.80 nM against JAK3 and 11.56 nM against TEC kinase interleukin-2-inducible T-cell kinase (ITK) respectively. |
| PC-22994 |
SB1578
JAK2/FLT3 inhibitor
|
SB1578 is a potent, selective JAK2/FLT3 inhibitor with IC50 of 46/60 nM respectively. |
| PC-22718 |
Coumermycin A1
JAK2 agonist
|
Coumermycin A1 (C-A1) is a small molecule JAK2 agonist that induces dimerization and activation of JAK2, also inhibits DNA Gyrase and cell division in bacteria. |
| PC-22634 |
CS12192
JAK//TBK1 inhibitor
|
CS12192 is a potent, selective JAK3/JAK1/TBK1 inhibitor with IC50 of 11/105/162 nM, respectively. |
| PC-22618 |
Oclacitinib maleate
JAK inhibitor
|
Oclacitinib (PF-03394197) maleate is a potent JAK inhibitor with IC50 of 10, 18, 99, and 84 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
| PC-22202 |
JAK3 inhibitor RB1
JAK3 inhibitor
|
JAK3 inhibitor RB1 is a potent, selective and irreversible JAK3 inhibitor with IC50 of 40 nM, without inhibiting JAK1, JAK2 or TYK2 (IC50>5000 nM). |
| PC-21900 |
CEP-33779
JAK2 inhibitor
|
CEP-33779 is a potent, selective, and orally bioavailable inhibitor of JAK2 with IC50 of 1.3 nM, 65-fold selective over JAK-3. |
| PC-21596 |
JNJ-64251330
JAK inhibitor
|
Lorpucitinib (JNJ-64251330) is potent, selective and orally bioavailable pan-JAK inhibitor with IC50 of 0.37/8.6/92/7.4 nM for JAK1/JAK2/JAK3/Tyk2 respectively. |
| PC-21425 |
WHI-P131
JAK3 inhibitor
|
WHI-P131 (JANEX-1) is a potent and selective JAK3 inhibitor with Ki of 2.3 uM and IC50 of 78 uM, with no activity agianst JAK1 and JAK2. |
| PC-21281 |
QL-1200186
TYK2-JH2 inhibitor
|
QL-1200186 is a potent, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 0.06 nM, targets pseudokinase regulatory domain (Janus homology 2, JH2) of the TYK2 protein. |
