| Cat. No. |
Product Name |
Information |
| PC-26017 |
NS-229
JAK1 inhibitor
|
NS-229 is a potent, selective JAK1 inhibitor with IC50 of 52 nM. |
| PC-25681 |
OB756
JAK2 inhibitor
|
OB756 (Bonretinib) is a potent, selective, oral JAK2 kinase inhibitor, inhibits cell proliferation and induces cell apoptosis, significantly inhibits the phosphorylation activity of p-STAT3 in the JAK-STAT signaling pathway. |
| PC-25191 |
Rovadicitinib
JAK/ROCK inhibitor
|
Rovadicitinib (TQ05105) is a potent, oral dual JAK1/2 and ROCK1/2 inhibitor targeting inflammatory and fibrotic components of chronic graft-versus-host disease (cGVHD). |
| PC-25095 |
Soficitinib
TYK2 inhibitor
|
Soficitinib (ICP-332) is a potent, selective second-generation tyrosine kinase 2 (TYK2) inhibitor, selectively binds to the ATP-binding site of the TYK2 JH1 domain over the highly homologous catalytic domains of other JAK family members. |
| PC-25094 |
Socrodeucitinib
TYK2 inhibitor
|
Socrodeucitinib (HS-10374) is a potent, selective, allosteric oral tyrosine kinase 2 (TYK2) inhibitor, binds to the pseudokinase domain of TYK2 with IC50 of 0.633 nM. |
| PC-25084 |
Quecitinib
JAK1/TYK2 inhibitor
|
Quecitinib (QY201) is a potent, selective dual JAK1/TYK2 inhibitor. |
| PC-25063 |
ESK-001 hydrochloride
TYK2 inhibitor
|
Envudeucitinib hydrochloride (ESK-001 hydrochloride) is a novel allosteric, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 104-149 nM in human whole blood, binds to JH2 domain of TYK2. |
| PC-25062 |
Envudeucitinib
TYK2 inhibitor
|
Envudeucitinib (ESK-001) is a novel allosteric, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) with IC50 of 104-149 nM in human whole blood, binds to JH2 domain of TYK2. |
| PC-25034 |
TUL01101
JAK1 inhibitor
|
Blovacitinib (TUL01101) is a potent, selective and oral Janus kinase 1 (JAK1) inhibitor with IC50 of 3 nM, >12-fold selectivity for JAK2 and TYK2. |
| PC-24937 |
Cenacitinib
TYK2 inhibitor
|
Cenacitinib (VTX-958) is a potent, highly selective, allosteric and orally bioavailable inhibitor of tyrosine kinase 2 (TYK2). |
| PC-24735 |
NMS-P953
JAK2 inhibitor
|
NMS-P953 is a potent and selective JAK2 inhibitor with IC50 of 8 nM, displays 18-, 4- and 18-fold selective over JAK1, JAK3 and TYK2 respectively. |
| PC-24348 |
cTYK2i Compound-A
TYK2 inhibitor
|
cTYK2i Compound-A (Cmpd-A) is a potent, specific and brain-penetrant TYK2 inhibitor (cTYK2i) with IC50 of 6.4 nM. |
