| Cat. No. |
Product Name |
Information |
| PC-43416 |
GSK2578215A
LRRK2 inhibitor
|
GSK2578215A is a highly potent, selective, BBB-permeable LRRK2 inhibitor with IC50 of 10.9 and 9.9 nM for wild-type LRRK2 and the G2019S mutant, respectively. |
| PC-42945 |
GNE-9605
LRRK2 inhibitor
|
GNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM. |
| PC-62508 |
PFE-360
LRRK2 inhibitor
|
PFE-360 (PF-06685360) is a potent, selective, brain-penetrating LRRK2 inhibitor with IC50 of 3 nM. |
| PC-62372 |
SR9444
LRRK2/JNK3 inhibitor
|
SR9444 is a small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK3 with IC50 of 100 nM and 12 nM respectively. |
| PC-42726 |
LRRK2-IN-1
LRRK2 inhibitor, PCNA inhibitor
|
LRRK2-IN-1 is a potent LRRK2 inhibitor with IC50s of 13 nM/6 nM for wild-type/G2019S mutant LRRK2 repectively (0.1 mM ATP in the assay), also induces cell cycle arrest and cancer cell death by specifically binding to human proliferating cell nuclear antigen (PCNA) in cancer cells. |
| PC-45094 |
JH-II-127
LRRK2 inhibitor
|
JH-II-127 is a potent and selective inhibitor of both wild-type and G2019S mutant LRRK2 with IC50 of 6.6 and 2.2 nM, respectively. |
| PC-45425 |
GNE-7915 tosylate
LRRK2 inhibitor
|
GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM. |
| PC-45424 |
GNE-7915
LRRK2 inhibitor
|
GNE-7915 is a highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM. |
| PC-24724 |
RN341
LRRK2 inhibitor
|
RN341 is a potent, selective, type II kinase inhibitor of LRRK2 with IC50 of 296 nM, binds to the kinase domain of LRRK2. |
| PC-24723 |
RN277
LRRK2 inhibitor
|
RN277 is a potent, selective, type II kinase inhibitor of LRRK2 with IC50 of 135 nM, binds to the kinase domain of LRRK2. |
| PC-24722 |
PF-06371900
LRRK2 inhibitor
|
PF-06371900 is a potent, highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor. |
| PC-24618 |
SRI-29132
LRRK2 inhibitor
|
SRI-29132 is a potent, highly selective and brain-permeable LRRK2 inhibitor with IC50 of 146 nM and 75 nM in WT LRRK2 and G2019S-LRRK2 cis-autophosphorylation kinase assays respectively. |
