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Cat. No. Product Name Information
PC-38626

IKAM-1

MAP3K1 inhibitor

IKAM-1 (Compound 39-100) is an orally bioavailable, small-molecule IKKβ activation modulator (IKAM) that selectively targets MAP3K1, inhibits TNF-α-induced IKKβ-mediated NF-κB activation in A549 cells with IC50 of 4.7 uM.
PC-72890

GDC-0134

DLK inhibitor

GDC-0134 (GDC0134) is a potent, selective, orally available, brain-penetrant inhibitor of dual leucine zipper kinase (DLK, MAP3K12).
PC-35427

GS-444217

ASK1 inhibitor

GS-444217 (GS444217) is a potent, selective, ATP-competitive, orally available inhibitor of ASK1 with Kd/IC50 of 4.1/2.87 nM.
PC-35394

TCASK10

ASK1 inhibitor

TCASK10 is a potent, highly specific inhibitor of ASK1 with IC50 of 14 nM, 30-fold selectivity over ASK2 (IC50=510 nM) and no activity against MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf.
PC-43286

GNE-3511

DLK inhibitor

GNE-3511 is a potent, selective, orally bioavailable, brain-penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of <0.5 nM, displays >100-fold selectivity over MKK4/7, JNK1/2/3, MLK1/2/3.
PC-62818

TAOK inhibitor 63

TAOK inhibitor

TAOK inhibitor 63 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively.
PC-62730

TAOK inhibitor 43

TAOK inhibitor

TAOK inhibitor 43 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 11 and 15 nM against TAOK1 and TAOK2, respectively.
PC-62729

SW-034538

TAOK2 inhibitor

SW-034538 is a potent TAOK2 (Thousand-And-One Kinase 2; MAP3K17) inhibitor with IC50 of 300 nM, has cross-reactivity with respect to six of the 45 kinases (Raf1, GSK3β, JNK1, IRAK4, HGK and CDK2).
PC-62728

SW-083688

TAOK2 inhibitor

SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM.
PC-62726

GSK-114

TNNI3K inhibitor

GSK-114 is a potent, selective TNNI3K (TNNI3 Interacting Kinase) inhibitor with IC50 of 25 nM, dispalys 40-fold over B-Raf, exceptional broad spectrum kinase selectivity (IC50>1,000 nM, 99% of kinases, 291/294).
PC-62541

MEKK2 inhibitor 1s

MEKK2 inhibitor

MEKK2 inhibitor 1s (MEKK2-IN-1s) is a potent MEKK2 (MAP3K2) inhibitor with IC50 of 16 nM, inhibits MEKK2 and MEKK3 with similar potencies.
PC-60165

MAP3K14-IN-173

NIK inhibitor

MAP3K14-IN-173 is a novel potent MAP3K14 kinase (NF-κB-inducing kinase, NIK) inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).

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