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Cat. No. Product Name Information
PC-35446

Dersimelagon

Dersimelagon (MT-7117) is an orally bioavailable selective, non-peptide melanocortin-1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human, cynomolgus monkey, mouse and rat MC1R, respectively.
PC-61573

ML00253764

MC4R inhibitor

ML00253764 is a non-peptide, brain penetrant melanocortin MC4 receptor (MC4R) antagonist with IC50 of 0.32, 0.81 and 2.12 uM for MC4, MC3 and MC5 receptors, respectively.
PC-60215

BMS-470539

MC-1R agonist

BMS-470539 is a potent, selective, full agonist of human and murine melanocortin-1 receptor (MC-1R) with EC50 of 16.8 and 11.6 nM, respectively.
PC-60214

PF-00446687

PF-00446687 (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
PC-60213

PF-00446687 hydrochloride

PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
PC-45520

Bremelanotide acetate

Bremelanotide acetate is an analogue of the naturally occurring peptide alpha-MSH.
PC-45743

Setmelanotide

Melanocortin receptor agonist

Setmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin receptor agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively.
PC-21480

MCL0020

MC4R inverse agonist

MCL0020 is a potent, selective inverse agonist of melanocortin MC4 receptor (MC4R) with binding IC50 of 11.6 nM, shows negligible affinity for MC1 and MC3 receptors.
PC-49762

SNT-207707

MC4R inhibitor

SNT-207707 (SNT207707) is a potent, selective, BBB-penetrating, and orally active melanocortin-4 (MC-4) receptor antagonist with binding/fuaction IC50 of 8/5 nM, respectively.
PC-49761

SNT-207858

MC4R inhibitor

SNT-207858 (SNT207858) is a potent, selective, BBB-penetrating, and orally active melanocortin-4 (MC-4) receptor antagonist with binding/fuaction IC50 of 22/11 nM, respectively.
PC-49760

PF-07258669

MC4R inhibitor

PF-07258669 (PF 07258669) is a potent, selective, and orally bioavailable melanocortin-4 receptor (MC4R) antagonist with Ki of 0.46 nM and human MC4R inverse agonist potency (IC50=13 nM).
PC-49060

TCMCB07

MC4R antagonist

TCMCB07 is a synthetic, cyclic nonapeptide peptide antagonist of the melanocortin-4 receptor (MC4R), ameliorates cancer- and chronic kidney disease-associated cachexia.

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