| Cat. No. |
Product Name |
Information |
| PC-42619 |
Lexibulin
|
An orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. |
| PC-45982 |
Cephalomannine
|
A taxol derivative with antitumor, antiproliferative properties. |
| PC-42466 |
Ixabepilone
|
A semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer. |
| PC-45256 |
4|-Demethylepipodophyllotoxin
|
A potent inhibitor of microtubule assembly, and a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer compounds.. |
| PC-45268 |
Fosbretabulin disodium
|
A derivative of combretastatin that acts as a microtubule destabilising agent. |
| PC-45239 |
Vinblastine
|
A cytotoxic alkaloid that binds tubulin and inhibits the assembly of microtubules. |
| PC-45151 |
Epothilone B
|
A blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells. |
| PC-21448 |
TN-2
Tubulin/NRP1 inhibitor
|
TN-2 is a potent, dual tubulin/NRP1-targeting inhibitor with IC50 of 0.71 uM (tubulin polymerization) and 0.85 uM (NRP-1), inhibits proliferation and angiogenesis of tumor cells. |
| PC-21390 |
Plinabulin
Tubulin inhibitor
|
Plinabulin (NPI-2358) is a small molecule vascular disrupting agent against tubulin-depolymerizing, shows IC50 of 9.8 nM against HT-29 cells. |
| PC-21389 |
BNC105
Tubulin inhibitor
|
BNC105 is a small molecule tubulin polymerization inhibitor (IC50=3.0 uM) with potent antiproliferative and tumor vascular disrupting properties. |
| PC-21388 |
KGP618
Tubulin inhibitor
|
KGP618 is the phosphate prodrug salt of KGP591, which is a small molecule inhibitor of tubulin polymerization with IC50 of 0.57 uM. |
| PC-21387 |
KGP591
Tubulin inhibitor
|
KGP591 is a small molecule inhibitor of tubulin polymerization with IC50 of 0.57 uM, exhibits cytotoxicity against the MCF-7 and MDA-MB-231 human breast cancer cell lines with GI50 of 320 and 102 nM, respectively. |
