| Cat. No. |
Product Name |
Information |
| PC-42619 |
Lexibulin
Tubulin inhibitor
|
Lexibulin (CYT997) is an orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. |
| PC-45982 |
Cephalomannine
Microtubule stabilizer
|
Cephalomannine is taxol derivative with antitumor, antiproliferative properties, is active in promoting microtubule assembly. |
| PC-42466 |
Ixabepilone
Microtubule stabilizer, TUBB3 inhibitor
|
Ixabepilone (Azaepothilone B, BMS-247550) is a semisynthetic Epothilone B analogue and potent, orally active microtubule stabilizer, also is a TUBB3 inhibitor. |
| PC-45256 |
4-Demethylepipodophyllotoxin
Microtubule inhibitor
|
4'-Demethylepipodophyllotoxin (4'-DMEP) is a potent inhibitor of microtubule assembly, and a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer compounds. |
| PC-45268 |
Fosbretabulin disodium
Microtubule inhibitor
|
Fosbretabulin disodium (CA4DP, Combretastatin A-4) is a derivative of combretastatin that acts as a microtubule destabilising agent, damages the vasculature (blood vessels) of cancer tumours causing central necrosis. |
| PC-45239 |
Vinblastine
Microtubule inhibitor
|
Vinblastine is a cytotoxic alkaloid that binds tubulin and inhibits the assembly of microtubules, a chemotherapy agent for treatment of a number of types of cancer. |
| PC-45151 |
Epothilone B
Microtubule stabilizer
|
Epothilone B (EPO-906, Patupilone) blood-brain barrier-permeable microtubule-stabilizing agent that promotes tubulin polymerization and induces G2-M cell cycle arrest with EC50 of 32 nM in HeLa cells. |
| PC-25361 |
Tubulin inhibitor 89
Tubulin inhibitor
|
Tubulin inhibitor 89 is a novel potent colchicine-site inhibitor of tubulin, has significant cytostatic activity against human Hela (cervical) and HCT116 (colonic) tumor cells with IC50 of 1.13 and 0.65 uM respectively, interferes with the assembly of microtubules by inhibiting PI3K/Akt signaling pathway. |
| PC-24654 |
RGN6024
Tubulin destabilizer
|
RGN6024 is a brain-penetrant, small molecule tubulin destabilizer, binds the colchicine binding site of tubulin, displays high potency against GB cell lines. |
| PC-24416 |
Tubulin inhibitor No.07
Tubulin inhibitor
|
Tubulin inhibitor No.07 is a novel tubulin inhibitor, irectly binds to tubulin dimers and interferes with microtubule polymerization, shows anti-cancer and anti-metastatic effects in colon cancer and tumoroids (Hela cell IC50=455 nM). |
| PC-24239 |
IMB5046
Microtubule inhibitor
|
IMB5046 is a novel nitrobenzoate microtubule inhibitor, inhibits tubulin polymerization and shows cytotoxicity against multidrug-resistant cell lines in vitro and in vivo. |
| PC-24204 |
TUBG1 inhibitor L12
γ-tubulin1 inhibitor
|
TUBG1 inhibitor L12 is a specific inhibitor of γ-tubulin1 (TUBG1) and γ-tubule polymerizing agent, selectively inhibits TUBG1 activity in RB1-deficient tumor cells without affecting TUBG2. |
