| Cat. No. |
Product Name |
Information |
| PC-36153 |
ML090
NOX1 inhibitor
|
ML090 (ML-090, CCG-44699, Fluoflavin, NSC 179821) is a potent, selecitve inhibitor of NADPH oxidase 1 (NOX1) with IC50 of 90 nM, displays no significant activities against NOX2, 3 and 4 (IC50>10 uM). |
| PC-35364 |
GLX351322
Nox4 inhibitor
|
GLX351322 (GLX-351322) is a novel potent inhibitor of NADPH oxidase 4 (Nox4), inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 uM. |
| PC-42961 |
GKT137831
NOX1/4 inhibitor
|
GKT137831 (Setanaxib, GKT-137831) is a potent, selective, dual NADPH oxidase Nox1/4 inhibitor with Ki of 110/140 nM, 15-fold less potent on Nox2 and 3-fold less potent on Nox5, and no affinity for xanthine oxidase. |
| PC-61657 |
Imipramine Blue
STAT5 inhibitor, NOX inhibitor
|
Imipramine Blue is a potent STAT5 inhibitor with a dual mechanism of action, potently inhibits STAT5 through liberation of endogenous phosphatase activity following NADPH oxidase (NOX) inhibition at 200-300 nM. |
| PC-60724 |
VAS2870
NOX inhibitor
|
VAS2870 (VAS-2870) is a potent, specific NADPH oxidase (Nox) inhibitor, completely abolishes PDGF-mediated NAD(P)H oxidase activation and ROS production at 10-20 uM in vascular smooth muscle cells (VSMC). |
| PC-60723 |
ML171
NOX1 inhibitor
|
ML171 is a potent, specific, cell-active NADPH oxidase1 (Nox1) inhibitor that strongly blocks ROS generation in HT29 cells with IC50 of 0.129 uM. |
| PC-60410 |
APX-115
NADPH oxidase inhibitor
|
Isuzinaxib (APX-115, Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively. |
| PC-60409 |
APX-115 freebase
NADPH oxidase inhibitor
|
APX-115 freebase (Isuzinaxib, Ewha 18278) is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively. |
| PC-45569 |
GSK2795039
NOX2 inhibitor
|
GSK2795039 (GSK 2795039) is a potent and selective inhibitor of NOX2 (NADPH oxidase 2) with pIC50 of 6.57. |
| PC-28571 |
NOX5-IN-1
NOX5 inhibitor
|
NOX5-IN-1 (Compound 13) is a potent, selective NADPH oxidase 5 (NOX5) inhibitor with IC50 of 0.3 uM in cell-free assays, shows no activity against NOX1, NOX2 , NOX4, NOX5 and DUOX1 (IC50>10 uM). |
| PC-28570 |
MC4921
NOX2 inhibitor
|
MC4921 (Compound 2a) is a potent, selective NADPH oxidase 2 (NOX2) inhibitor with IC50 of 1.4 uM (hNOX2). |
| PC-28569 |
MC4876
NOX2 inhibitor
|
MC4876 is a potent, selective NADPH oxidase 2 (NOX2) inhibitor with IC50 of 7.7 uM (hNOX2), shows much weaker acitivty against hNOX1 (71.2 uM), hNOX4 (81.2 uM) and hNOX5 (28 uM). |
