| Cat. No. |
Product Name |
Information |
| PC-47491 |
Dynorphin A(1-13)
Neurolysin inhibitor, KOR agonist
|
Dynorphin A(1-13) is a potent, competitive peptidie inhibitor of Neurolysin (Nln) with IC50 of 1.2 uM, also is a kappa receptor agonist binds to human kappa opioid receptor (KOR) with Ki of 200 nM. |
| PC-26101 |
BNTX maleate
δ1-opioid receptor antagonist
|
BNTX (7-benzylidenenaltrexone) maleate is a selective δ1-opioid receptor antagonist with the Ki of 0.1 nM, >100-fold selective over δ2-, μ-, and κ-opioid receptors. |
| PC-26060 |
MPAM-15
μOR PAM
|
MPAM-15 is a potent, selective, brain penetrant positive allosteric modulator of μ-opioid (MOR) receptor with pEC50 of 9.9, >16-fold selectivity for μOR over δOR, κOR, and NOPR. |
| PC-24995 |
Naloxonazine dihydrochloride
MOR antagonist
|
Naloxonazine dihydrochloride is a potent, specific μ-opioid receptor (MOR) antagonist with IC50 of 5.4 nM, shows anti-leishmanial activity. |
| PC-24855 |
Matrine
ANXA2 inhibitor, Opioid receptor agonist
|
Matrine (Matridin-15-one) is a plant alkaloid that act as a kappa opioid receptor (KOR) and u-receptor (MOR) agonist, also directly targets Annexin A2 (ANXA2) with binding Kd of 12.8 uM, inhibits ANXA2-mediated PLG-PN conversion, shows anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. |
| PC-24153 |
[D-Arg2] Dermorphin (1-4) acetate
MOR agonist
|
[D-Arg2] Dermorphin (1-4) acetate (Lumekefamide) is a potent, selective tetrapeptide μ-opioid receptor (μOR, MOR) agonist, shows antinociceptive effects. |
| PC-24152 |
[D-Arg2] Dermorphin (1-4)
MOR agonist
|
[D-Arg2] Dermorphin (1-4) (Lumekefamide) is a potent, selective tetrapeptide μ-opioid receptor (μOR, MOR) agonist, shows antinociceptive effects. |
| PC-23788 |
Loperamide hydrochloride
mu-opioid receptor agonist
|
Loperamide hydrochloride (R-18553) is a potent, selective mu-opioid receptor (MOR) agonist, also is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor, shows anti-diarrheal effect. |
| PC-23693 |
DPDPE
DOR agonist
|
DPDPE is a potent, specific agonist of delta opioid receptor (DOR), shows anticonvulsant effects. |
| PC-23203 |
ADL06
DOR agonist
|
ADL06 is a selective small-molecule Gi protein-biased agonist/ ligand of delta opioid receptor (DOR, δOR) with pEC50 of 6.5 in Gi protein signal pathway, with ignificantly diminished effect on β-arrestin. |
| PC-23099 |
Icalcaprant
KOR antagonist
|
Icalcaprant (CVL-354) is a potent, selective kappa opioid receptor (KOR) antagonist with Ki of 1.47 nM and IC50 of 0.042 nM, 31-fold binding affinity selectivity over MOR. |
| PC-22956 |
Exoticin
6TM-μOR agonist
|
Exoticin is a selective agonist of 6TM μ opioid receptor (6TM-μOR) with Kd of 14 uM, induces 6TM-μOR-dependent signal transduction, shows broad-spectrum analgesic efficacy. |
