| Cat. No. |
Product Name |
Information |
| PC-70350 |
KNT-127
δ-opioid receptor agonist
|
KNT-127 is a potent, selective δ-opioid receptor (DOR) agonist with Ki of 0.16 nM, dispalys 133.5-fold and 960.5-fold selectivity over μOR and κOR respectively. |
| PC-70349 |
SNC80
δ-opioid receptor agonist
|
SNC80 (NIH-10815) is a highly selective, non-peptide agonist of the δ-opioid receptor (δ-OR) with IC50/Ki of 2.73/0.18 nM. |
| PC-60802 |
NKTR-181
MOR agonist
|
A novel, long-acting and orally active, selective mu-opioid agonist that displays higher binding affinity (Ki=237 nM) at the MOR than kappa and delta opioid receptors (>100-fold). |
| PC-60799 |
AT-403
|
AT-403 (AT403) is a potent, highly selective, nonpeptide NOP agonist with pEC50 of 9.45. |
| PC-60798 |
SCH 486757
ORL1 agonist
|
SCH 486757 is a potent, selective, orally active nociceptin/orphanin FQ peptide (NOP, ORL1) receptor agonist with Ki of 4.6 nM, with high selectiivity over classical opioid receptors. |
| PC-60737 |
Eluxadoline
μ-opioid receptor agonist
|
A potent, selective, orally bioavailable µ-opioid receptor agonist and a δ-opioid receptor antagonist for the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D).. |
| PC-43423 |
Alvimopan
|
Alvimopan (LY 246736) is a selective peripherally acting μ-opioid (MOR) antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus. |
| PC-42615 |
JDTic dihydrochloride
|
A highly potent and selective kappa Opioid receptor (KOR) antagonist with Ki of 0.3 nM. |
| PC-42614 |
JDTic
|
JDTic is a highly potent and selective kappa opioid receptor (KOR) antagonist with Ki of 0.3 nM. |
| PC-22000 |
LY2444296
KOR inhibitor
|
LY2444296 is a potent, selective orally bioavailable, and short-acting kappa opioid receptor (KOPR) antagonist with Ki of 1 nM. |
| PC-21949 |
Sunobinop
NOP agonist
|
Sunobinop is a potent and partial agonist of the nociceptin/orphanin FQ peptide receptor (NOP receptor) with Ki of 3.3 nM, EC50 of 4.03 nM. |
| PC-21793 |
LY2817412
NOP antagonist
|
LY2817412 is a potent, selective andorally active nociceptin/orphanin FQ (NOP) receptor antagonist with Ki of 0.176 nM, Kb of 0.273 nM in functional assay of receptor-mediated G-protein activation using [35S]-GTPγS binding. |
