| Cat. No. |
Product Name |
Information |
| PC-63123 |
Pterosin B
SIK3 inhibitor
|
Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain. |
| PC-63122 |
YKL-06-061
SIK inhibitor
|
YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 of 6.56/1.77/20.5 nM for SIK1/2/3, respectively. |
| PC-61952 |
ARN3261
SIK2/3 inhibitor
|
ARN3261 (GRN-300, ARN-3261) is a potent, selective, orally available salt inducible kinase SIK2 and SIK3 inhibitor with IC50 of 11 nM and 19 nM, respectively. |
| PC-61766 |
ARN-3236
SIK2 inhibitor
|
ARN-3236 (ARN3236) is a novel potent, selective, and orally active SIK2 inhibitor with IC50 of <1 nM. |
| PC-61765 |
MRT199665
SIK inhibitor
|
MRT199665 is a potent salt-inducible kinases (SIKs) inhibitor with IC50 of 110, 12, 43 nM for SIK1,2,3 respectively. |
| PC-42327 |
YKL-05-099
SIK inhibitor
|
YKL-05-099 (YKL 05-099) is a novel potent, selective pan-SIK inhibitor with IC50 of 10, 40 and 30 nM for SIK1, SIK2 and SIK3, respectively. |
| PC-25523 |
SIK1 inhibitor 27
SIK1 inhibitor
|
SIK1 inhibitor 27 is a potent, isoform-selective SIK1 inhibitor with IC50 of 0.7 nM, >100-fold selectivity against SIK2 and SIK3. |
| PC-25119 |
SIK2-3 inhibitor 7s
SIK2/3 inhibitor
|
SIK2/3 inhibitor 7s is a potent, selective dual SIK2/3 inhibitor with IC50 of 1.1 nM for both, >30-fold selective over SIK1. |
| PC-24280 |
SIK inhibitor 7s
SIK2/3 inhibitor
|
SIK inhibitor 7s is a potent, selective inhibitor of SIK2/SIK3 with IC50 of 1.1 nM for both, inhibits SIK1 with IC50 of 34.5 nM. |
| PC-20809 |
SIK inhibitor M22
pan-SIK inhibitor
|
SIK inhibitor M22 is a potent, selective pan-SIK (salt-inducible kinase) with IC50 of 72, 89 and 18 nM for SIK1, SIK2 and SIK3 in NanoBERT assays, respectively. |
