| Cat. No. |
Product Name |
Information |
| PC-73327 |
CD33 splicing modulator 1
CD33 splicing modulator
|
CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein. |
| PC-73161 |
Thailanstatin D
ADC cytotoxin
|
Thailanstatin D (TST-D) is a potent antiproliferative natural product and direct precursor of Thailanstatin A, inhibits eukaryotic RNA splicing with stiong anti-tumor activities. |
| PC-72029 |
UHMCP1
SF3b155/U2AF65 inhibitor
|
UHMCP1 is a small molecule that prevents the SF3b155/U2AF65 interaction, binds to the hydrophobic pocket of the U2AF65 UHM domain (Kd=1-20 uM), impacts splicing and cell viability. |
| PC-38037 |
FR901465
|
FR901465 is an antitumor agent isolated from the fermentation broth of Pseudomonas sp. No. 2663, a splicing modulator with strong anticancer activities.. |
| PC-62507 |
Isoginkgetin
|
Isoginkgetin (Iso-ginkgetin. |
| PC-62422 |
Sudemycin K
|
Sudemycin K is a synthetic antitumor splicing inhibitor with IC50 of 15 nM (MCL1 alternative splicing regulation), shows cytotoxicity in HeLa cells with IC50 of 2.3 nM. |
| PC-62421 |
Sudemycin E
|
Sudemycin E is an alternative splicing inhibitor that binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1, causes a rapid change in alternative pre-messenger RNA splicing. |
| PC-62420 |
FR-901464
|
FR-901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases.. |
| PC-62419 |
Meayamycin
|
Meayamycin is an analogue of FR901464 that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, shows picomolar antiproliferative activity against various cancer cell lines and multidrug-resistant cells.. |
