| Cat. No. |
Product Name |
Information |
| PC-20159 |
M4205
KIT mutations inhibitor
|
M4205 (IDRX-42) is a potent, highly selective inhibitor of KIT mutations with cell IC50 of 52 nM on cKIT autophosphorylation in the GIST430/654 cell line. |
| PC-35661 |
AZD3229
pan-KIT mutant inhibitor
|
AZD3229 (AZD-3229) is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM). |
| PC-35619 |
BPR1J373
Multikinase inhibitor
|
BPR1J373 is a potent, orally available multitargeted kinase inhibitor, potently inhibits FLT3, c-KIT, VEGFR1-3, Aurora A, PDGFRα, PDGFRβ, RET, and SRC with IC50 values of <100 nM. |
| PC-62597 |
Famitinib
|
Famitinib (SHR1020) is a structural analogue of sunitinib, novel and potent multi-targeted RTK inhibitor, including c-Kit, VEGFR2/3, PDGFRβ, FLT-1/3 receptor and c-RET. |
| PC-62101 |
DCC-2618
KIT inhibitor
|
DCC-2618 (Ripretinib) is a potent, oral inhibitor of singly and doubly mutated KIT with IC50 of WT (IC50=4 nM), V654A (8 nM), T670I (18 nM), D816H (5 nM), D816V. |
| PC-62100 |
Avapritinib
mutant KIT inhibitor
|
Avapritinib (BLU-285) is a potent and highly selective inhibitor of mutant KIT and PDGFRα with IC50 of 0.6, 0.27 and 0.24 nM for KIT del557-558, KIT D816V and PDGFRA D842V, respectively. |
| PC-42449 |
OSI-930
c-Kit inhibitor
|
A potent, orally active, dual inhibitor of c-Kit and VEGFR-2 (KDR) with IC50 of 15 nM and 9 nM, respectively. |
| PC-42454 |
Masitinib
|
Masitinib (AB1010) is a potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays. |
| PC-45100 |
Sitravatinib
Multikinase inhibitor
|
Sitravatinib (MGCD-516) is a broad spectrum small molecule inhibitor that blocks a wide array of RTKs known to be amplified/overexpressed in sarcomas, including c-Kit, PDGFRβ, PDGFRα, c-Met, and Axl (IC50=1.5-30 nM). |
| PC-42451 |
Amuvatinib
c-Kit inhibitor
|
Amuvatinib (MP-470) is a potent RTK inhibitor that effectively inhibits c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. |
| PC-21781 |
BLU-808
c-Kit inhibitor
|
BLU-808 is a potent and selective wt c-KIT inhibitor, potently inhibits c-KIT–dependent phosphorylation and proliferation with IC50 values in the sub-nanomolar and nanomolar range, respectively. |
| PC-20030 |
BLU-263
KIT D816V inhibitor
|
Elenestinib (BLU-263, BLU263) is a potent, selective, oral next-generation KIT D816V inhibitor with IC50 of 0.2 nM. |
