| Cat. No. |
Product Name |
Information |
| PC-20949 |
IEM1460
AMPAR inhibitor
|
IEM-1460 is a selective GluA2-lacking AMPAR inhibitor, blocks Ca2+ permeable AMPA receptors (AMPARs). |
| PC-49068 |
UBP684
NMDAR PAM
|
UBP684 is a positive allosteric modulator of N-methyl-D-aspartate receptor (NMDAR), potentiates GluN2A-D NMDAR responses evoked by low agonist concentrations L-glutamate and glycine with EC50 values of 30 uM, and a maximal potentiation of 69 to 117%. |
| PC-49067 |
UBP792
NMDAR NAM
|
UBP792 is a novel negative allosteric modulator (antagonist) of NMDA receptors, displays partial subtype-selectivity by having a varied maximal inhibition of GluN2A-, GluN2B-, GluN2C-, and GluN2D-containing receptors (52%, 70%, 87%, 89%, respectively) with IC50 values of 4-10 uM. |
| PC-49066 |
GNE-9278
NMDAR PAM
|
GNE-9278 is a potent NMDAR positive allosteric modulator (PAM) that acts at the GluN1 transmembrane domain (TMD), robustly potentiates GluN2A, 2B, 2C and 2D-containing NMDARs in calcium influx assays from HEK cell lines with EC50 values of 0.74, 3.07, 0.47, and 0.32 μM, respectively, and maximum fold potentiation of 5.5, 8.4, 10.2 and 7.9, respectively. |
| PC-49065 |
PTC-174
GluN2C/2D PAM
|
PTC-174 is a selective, positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits with EC50 of 4.1 uM (GluN1/2C) and 5.7 uM (GluN1/2D). |
| PC-49064 |
PYD-106
GluN2C PAM
|
PYD-106 is a GluN2C-selective NMDA receptor positive allosteric modulator, enhances the maximal current response of GluN1/GluN2C receptors. |
| PC-49063 |
SAGE-718
NMDAR PAM
|
SAGE-718 is a potent and high intrinsic activity N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 86 and 79 nM for GluN2A and GluN2B, respectively, reverses DOI-induced increases in locomotor activity. |
| PC-73198 |
QNZ46
GluN2C/D inhibitor
|
QNZ46 is a noncompetitive antagonist of NMDA receptor, selectively inhibits GluN2C/D-containing receptors with IC50 of 3.2/3.9 uM, repectively. |
| PC-72104 |
NP10679
GluN2B inhibitor
|
NP10679 (NP 10679) is a potent, orally active, NMDA receptor subunit 2B (GluN2B)-selective inhibitor of NMDA receptor with IC50 of 23 nM, with no significant effect on GluN2A/C/D (IC50>100 uM). |
| PC-35544 |
S44819
|
S44819 (S-44819, Egis-1352 Afizagabar) is a novel potent, competitive, selective antagonist of the α5-GABAAR with Kd of 221 nM, IC50 of 585 nM (α5β2γ2). |
| PC-63207 |
NAB-14
GluN2C/2D modulator
|
NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors. |
| PC-42958 |
PEAQX tetrasodium hydrate
|
PEAQX (NVP-AAM077) is a potent, selective, NR2A-preferring NMDA receptor antagonist with IC50 of 270 nM (NR1A/2A), >100-fold selectivity over NR1A/2B receptor (IC50=29,600 nM). |
