| Cat. No. |
Product Name |
Information |
| PC-23269 |
EU1622-240
NMDAR PAM
|
EU1622-240 is a positive allosteric modulator of NMDA receptors (NMDARs), preferentially potentiate GluN2B-, GluN2C-, and GluN2D-containing NMDARs with EC50 of 0.57 uM, 0.82 uM and 1.1 uM respectively. |
| PC-22450 |
TCN201
GluN2A antagonist
|
TCN201 is a selective GluN2A-containing NMDARs antagonist with pIC50 of 6.8 uM for GluN1/GluN2A NMDAR, negligible effect on GluN1/GluN2B NMDA receptor. |
| PC-22292 |
TAK-653
AMPAR PAM
|
TAK-653 (NBI-1065845, Osavampator) is a potent, selective AMPA receptor positive allosteric modulator/potentiator, induces Ca2+ influx in hGluA1i CHO cells with EC50 of 2.2 uM. |
| PC-21854 |
FP802
TwinF interface inhibitor
|
FP802 is a potent neuroprotectant and small molecule inhibitor of TwinF interface, shows selective elimination of eNMDAR-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex, while sparing the vital physiological functions of synaptic NMDARs. |
| PC-21853 |
Zelquistinel
NMDAR modulator
|
Zelquistinel (AGN-241751) is an orally active NMDAR allosteric modulator, exhibits antidepressant-like activity via positive modulation of GluN2B containing NMDARs in mPFC excitatory neurons. |
| PC-21623 |
ZCAN262
GluA2 modualtor
|
ZCAN262 is a small molecule that prevents AMPA-mediated excitotoxicity (IC50=8.5 nM) by targeting an allosteric binding site of AMPA glutamate receptor 2 (GluA2). |
| PC-21030 |
(S)-(-)-DQP-997-74
GluN2C/2D NAM
|
(S)-(-)-DQP-997-74 is a potent, selective GluN2C- and GluN2D-containing NMDARs negative allosteric modulator with IC50 of 69 and 35 nM, respectively, exhibits >100- and >300-fold over GluN2A- and GluN2B-containing receptors. |
| PC-20949 |
IEM1460
AMPAR inhibitor
|
IEM-1460 is a selective GluA2-lacking AMPAR inhibitor, blocks Ca2+ permeable AMPA receptors (AMPARs). |
| PC-20695 |
NYX-2925
NMDAR PAM
|
NYX-2925 (NYX2925) is a potent, specific NMDAR positive allosteric-modulator, facilitates [3H] MK-801 binding in all four human NMDAR2 subtypes with EC50 of 55 pM, 28 fM, 11 pM, and 55 pM for hNR2A, 2B, 2C, and 2D receptors, respectively. |
| PC-20370 |
GNE-5729
GluN2A PAM
|
GNE-5729 (GNE5729) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 37 nM. |
| PC-20369 |
GNE-0723
GluN2A PAM
|
GNE-0723 (GNE0723) is a potent, brain penetrant GluN2A-selective NMDAR positive allosteric modulator with EC50 of 21 nM. |
| PC-20368 |
GluN2A PAM (R)-9
GluN2A PAM
|
GluN2A PAM (R)-9 is a potent, brain penetrant, GluN2A-selective positive allosteric modulator with EC50 of 0.51 uM, Emax 350%. |
