| Cat. No. |
Product Name |
Information |
| PC-72170 |
AP-202
α4β2 antagonist
|
AP-202 (AP202) is a highly potent and selective α4β2 nAChR antagonist with binding Ki of 18 nM, 57-fold selectivity over α3β4 receptor. |
| PC-72169 |
SUVN-911
α4β2 antagonist
|
SUVN-911 (Ropanicant) is a novel, potent, selective, orally active α4β2 nAChR receptor antagonist with Ki of 1.5 nM. |
| PC-38317 |
α7nAChR PAM 28
α7 nAChR modulator
|
α7nAChR PAM 28 is a novel potent, brain-permeable, orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR) with EC50 of 0.32 uM. |
| PC-63394 |
JNJ-39393406
α7 nAChR modulator
|
JNJ-39393406 is a potent, selective positive allosteric α7 nAChR modulator, potentiates a 100 μM choline-induced rise in intracellular calcium mediated by human α7 channels expressed in GH4C1 cells with EC50 of 660 nM. |
| PC-43108 |
PNU-282987
α7 nAChR agonist
|
PNU-282987 is a potent, selective α7 nAChR agonist with Ki of 26 nM, shows negligible block of α1β1γδ and α3β4 nAChRs (IC50>60 uM). |
| PC-42901 |
PNU-120596
α7 nAChR PAM
|
PNU-120596 (NSC 216666) is a potent, selective α7 nAChR positive allosteric modulator (PAM) that enhances ACh-evoked Ca2+ flux with EC50 of 216 nM, displays no activity for α3β4, α4β2 and α9β10 nAChRs. |
| PC-61620 |
ABT 089 dihydrochloride
|
ABT 089 dihydrochloride (Pozanicline) is a potent and selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR. |
| PC-61619 |
ABT-089
|
ABT-089 (Pozanicline) is a potent, selective α4β2 nAChR agonist with Ki of 16 nM. |
| PC-61600 |
AQW-051
α7 nAChR agonist
|
AQW-051 (VQW-765) is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56. |
| PC-42788 |
ZSET1446
Acetylcholine activator
|
Ismidenon (ZSET1446, ST-101) is a small molecule cognitive enhancer that potentiates acetylcholine-mediated facilitation of inhibitory synaptic transmission in the hippocampal neurons. |
| PC-26760 |
Varenicline Tartrate
α4β2 nAChR agonist
|
Varenicline Tartrate (CP 526555) is a potent, orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) with IC50 of 250 nM, is also a partial agonist of α6β2 nAChR and a full agonist of α7β2 nAChR. |
| PC-26759 |
Varenicline
α4β2 nAChR agonist
|
Varenicline (CP 526555) is a potent, orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR) with IC50 of 250 nM, is also a partial agonist of α6β2 nAChR and a full agonist of α7β2 nAChR. |
