| Cat. No. |
Product Name |
Information |
| PC-60179 |
EX-229
AMPK activator
|
EX-229 is a small molecule AMPK activator that dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes at 50 uM. |
| PC-60138 |
PF-739
AMPK activator
|
PF-739 (PF739) is a potent, pan-AMPK activator with similar potency for all AMPK heterotrimers, increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM. |
| PC-60137 |
MK-8722
AMPK activator
|
MK-8722 is a potent, selective, allosteric pan-AMPK activator with EC50 of 1-60 nM for all 12 mammalian AMPK isoforms. |
| PC-45830 |
A-769662
AMPK activator
|
A-769662 is a small molecule AMPK activator that directly stimulates partially purified rat liver AMPK (EC50=0.8 uM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50=3.2 uM). |
| PC-45055 |
ZLN-024 hydrochloride
AMPK activator
|
ZLN-024 hydrochloride is a potent, allosteric AMPK activator that has no effect on mitochondrial function or the ADP/ATP ratio, directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively. |
| PC-45054 |
ZLN-024
AMPK activator
|
ZLN-024 is a potent, allosteric AMPK activator that has no effect on mitochondrial function or the ADP/ATP ratio, directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively. |
| PC-21279 |
WZ4003
NUAK inhibitor
|
WZ4003 is a potent, highly specific protein kinase inhibitor of NUAK kinase with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively. |
| PC-20481 |
Metformin
AMPK activator
|
Metformin (1,1-Dimethylbiguanide) is a traditional anti-diabetic drug, functions by inhibiting complex I in the mitochondrial respiratory chain, activates AMPK and enhances insulin sensitivity. |
| PC-20056 |
BI-9774
AMPK activator
|
BI-9774 (BI 9774) is a potent pan-AMPK activator with EC50 of 64 nM in an ADP-Glo kinase assay with human AMPK (α1β1γ1) and EC50 of 8 nM in a cellular GLUT4 translocation assay. |
| PC-47025 |
PXL770 monohydrate potassium salt
AMPK activator
|
PXL770 is a novel orally bioavailable, small-molecule direct AMPK activator with EC50 of 16.2, 42.1 and 64 nM for α1β1γ1, α1β1γ2 and α1β1γ3, directly increases AMPK activity by both allosteric activation and protection from dephosphorylation. |
| PC-38551 |
IMM-H007
AMPK activator
|
IMM-H007 (H007, WS070117) is a novel lipid-lowering agent and AMPK activator, reduces serum lipid levels and inhibits lipid accumulation both in vitro and in vivo. |
| PC-38548 |
Debio 0930
AMPK activator
|
Debio 0930 (MY 63-78) is a specific and potent direct AMPK activator, allosterically activates AMPK activity in prostate cancer cells with EC50 of 25 uM, without altering the energy levels. |
