| Cat. No. |
Product Name |
Information |
| PC-45627 |
FPS-ZM1
RAGE inhibitor
|
FPS-ZM1 is a high-affinity RAGE-specific inhibitor with Ki of 25 nM, blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo. |
| PC-24359 |
OAB-14
Aβ modulator
|
OAB-14 is a bexaroten derivative that reduces the deposition of Aβ, promotes microglia phagocytosis and increasing IDE and NEP expression. |
| PC-23579 |
Licochalcone B
Aβ42 inhibitor
|
Licochalcone B is an extract from the root of Glycyrrhiza uralensis, inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduces metal-induced Aβ42 aggregation through chelating metal ions. |
| PC-23221 |
TZ095
Aβ fluorescent probe
|
TZ095 is a coumarin-based Aβ fluorescent probe for precise Aβ detection, exhibits remarkable affinity with Aβ aggregates (Kd = 81.54 nM for oligomers; Kd = 66.70 nM for fibril) and substantial fluorescence enhancement (F/F0 = 44). |
| PC-23194 |
anti-Aβ molecule M30
Aβ inhibitor
|
anti-Aβ molecule M30 is a small anti-Aβ molecule, binds to Aβ1-42 tetramer through hydrogen bonds resulting in a conformational stable Aβ1-42-M30 complex, prevent synaptotocity, improving AD-affected mice memory. |
| PC-23152 |
wact-190
Amyloid inhibitor
|
wact-190 is a small molecule inhibitor of amyloid aggregation. |
| PC-22533 |
C05-05
α-synuclein imaging agent
|
C05-05 is a small molecule imaging agent for α-synuclein pathologies for in vivo optical visualization of α-synuclein inclusions and tracking of pathological α-synuclein propagation. |
| PC-22406 |
ROF2
Amyloid probe
|
ROF2 is an aggregation-induced emission (AIE) small molecule, functionalities as an amyloid probe and a screening tool for amyloid inhibitors using different biophysical, cellular, and worm assays. |
| PC-21685 |
SRI-42667
Tau-SH3 inhibitor
|
SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability. |
| PC-21401 |
DDQ
Aβ-Drp1 inhibitor
|
DDQ is a small molecule inhibitor of binding sites of Amyloid beta (Aβ) and Drp1, reduces interaction between Aβ and Drp1, shows anti-aging effects. |
| PC-20803 |
MeSC-04
α-synuclein inhibitor
|
MeSC-04 is a potent α-Syn amyloid formation inhibitor, reduces the number and size of amyloid fibrils in vitro. |
