| Cat. No. |
Product Name |
Information |
| PC-62065 |
MRS2485
Aβ inhibitor
|
MRS 2485 is a potent, irreversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.. |
| PC-60873 |
BIOD303
α-synuclein modulator
|
BIOD303 is a novel conformational modulator of α-synuclein with EC50 of 105 uM, potentially outcompetes spermine in binding to α-synuclein. |
| PC-45445 |
ARN-2966
|
ARN-2966 is a potent, BBB penetrant post-transcriptional modulator of APP expression in transfected CHO cells that produce amyloid precursor protein (APP). |
| PC-45627 |
FPS-ZM1
|
FPS-ZM1 is a high-affinity RAGE-specific inhibitor. |
| PC-21685 |
SRI-42667
Tau-SH3 inhibitor
|
SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability. |
| PC-21679 |
Synucleozid-2.0
α-synuclein inhibitor
|
Synucleozid-2.0 is a drug-like small molecule that decreases α-synuclein levels by inhibiting ribosomes from assembling onto SNCA mRNA. |
| PC-21401 |
DDQ
Aβ-Drp1 inhibitor
|
DDQ is a small molecule inhibitor of binding sites of Amyloid beta (Aβ) and Drp1, reduces interaction between Aβ and Drp1, shows anti-aging effects. |
| PC-20803 |
MeSC-04
α-synuclein inhibitor
|
MeSC-04 is a potent α-Syn amyloid formation inhibitor, reduces the number and size of amyloid fibrils in vitro. |
| PC-20458 |
CNB-001
|
CNB-001 is a pyrazole derivative of curcumin with neuroprotective properties, inhibits extracellular Aβ toxicity in hippocampal neurons with EC50 of 400 nM. |
| PC-38734 |
Senile plaques (SPs) probe BSB
Aβ-specific ligand
|
Senile plaques (SPs) probe BSB is a chemical probe that can detect accumulation of Aβ in senile plaques (SPs) in vivo, exhibits high binding affinity for Aβ aggregates in vitro (Ki=0.4 uM). |
| PC-38480 |
TAE-1
Amyloid-beta modulator
|
TAE-1 is a sym-triazine-derived aggregation modulator, destabilizes Aβ1-42 assembly and inhibits amyloid-β fibril formation, also inhibits acetylcholinesterase (AChE) activity in SH-SY5Y neuronal cells. |
| PC-38408 |
ALI6
Aβ-LilrB2 inhibitor
|
ALI6 (Fluspirilene, Aβ-LilrB2 interaction inhibitor 6) is a small molecule Aβ-LilrB2 interaction inhibitor with Ki of 320 nM, blocks LilrB2 induced cell attachment and inhibit toxicity of Aβ. |
