| Cat. No. |
Product Name |
Information |
| PC-61321 |
CCT-031374 hydrobromide
beta-catenin inhibitor
|
A novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay. |
| PC-61288 |
Tegavivint
β-catenin/TBL1 inhibitor
|
Tegavivint (BC-2059, Tegatrabetan) is an orally bioavailable β-catenin antagonist that disrupts the binding of β-catenin to transducin β-like 1 (TBL1) and promotes β-catenin degradation, attenuates nuclear and cytoplasmic levels of β-catenin. |
| PC-70120 |
PRI-724
CBP/beta-catenin inhibitor
|
PRI-724 (Foscenvivint, OP-724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM. |
| PC-70092 |
KYA1797K
Wnt/β-catenin inhibitor
|
KYA1797K is a derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling. |
| PC-70091 |
KY1220
Wnt/β-catenin inhibitor
|
KY1220 is a small molecule destabilizer of both β-catenin and Ras via inhibition of the Wnt/β-catenin pathway (IC50=2.1 uM). |
| PC-42398 |
LF3
β-catenin/TCF4 inhibitor
|
LF3 is a small-molecule antagonist of the β-catenin/TCF4 interaction with IC50 of 1.65 and 1.82 uM in AlphaScreen and ELISA assay, respectively. |
| PC-42676 |
IQ-1
p300/β-catenin inhibitor
|
IQ-1 is a small molecule, specific inhibitor of p300/β-catenin interaction that binds to PR72/130 subunit of PP2A. |
| PC-42324 |
PNU-74654
Tcf/β-catenin inhibitor
|
PNU-74654 (PNU74654) is a potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction binds to β-catenin with Kd of 450 nM. |
| PC-45815 |
Triptonide
beta-catenin inhibitor
|
Triptonide (NSC 165677, PG 492) is a key bioactive small molecule identified in Tripterygium wilfordii Hook F., has a broad spectrum of biological functions, inhibits canonical Wnt/β-catenin signaling by targeting β-catenin. |
| PC-27586 |
ZW4864 hydrochloride
β-catenin/BCL9 inhibitor
|
ZW4864 hydrochloride (ZW-4864 hydrochloride) is an orally bioavailable small-molecule that binds with β-catenin and selectively disrupts the PPI between BCL9 and β-catenin, while sparing the β-catenin/E-cadherin PPI. |
| PC-26729 |
YH250
p300/catenin antagonist
|
YH250 is a specific small molecule inhibitor of p300/catenin interaction, enhances hematopoietic recovery after radiation. |
| PC-23845 |
beta-catenin inhibitor MSAB
β-catenin inhibitor
|
MSAB is a selective, direct inhibitor of Wnt/β-catenin signaling, binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. |
