Cat. No. |
Product Name |
Information |
PC-61322 |
CGP049090
β-catenin/LEF1 inhibitor
|
CGP049090 (Cercosporin) is a small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines. |
PC-61321 |
CCT-031374 hydrobromide
beta-catenin inhibitor
|
A novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay. |
PC-61288 |
Tegatrabetan
beta-catenin inhibitor
|
Tegatrabetan (BC-2059, BC2059, Tegavivint) is an orally bioavailable β-catenin antagonist that disrupts the binding of β-catenin to TBL1 and promotes β-catenin degradation, attenuates nuclear and cytoplasmic levels of β-catenin. |
PC-70120 |
PRI-724
CBP/beta-catenin inhibitor
|
PRI-724 (Foscenvivint, OP-724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM. |
PC-70092 |
KYA1797K
Wnt/β-catenin inhibitor
|
KYA1797K is a derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling. |
PC-70091 |
KY-1220
Wnt/β-catenin inhibitor
|
KY-1220 is a small molecule destabilizer of both β-catenin and Ras via inhibition of the Wnt/β-catenin pathway (IC50=2.1 uM). |
PC-42398 |
LF3
β-catenin/TCF4 inhibitor
|
A small-molecule antagonist of the β-catenin/TCF4 interaction with IC50 of 1.65 and 1.82 uM in AlphaScreen and ELISA assay, respectively. |
PC-42676 |
IQ-1
p300/β-catenin inhibitor
|
A small molecule, specific inhibitor of p300/β-catenin interaction that binds to PR72/130 subunit of PP2A. |
PC-42324 |
PNU-74654
Tcf/β-catenin inhibitor
|
PNU-74654 (PNU74654) is a potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction binds to β-catenin with Kd of 450 nM. |
PC-45815 |
Triptonide
beta-catenin inhibitor
|
Triptonide (NSC 165677, PG 492) is a key bioactive small molecule identified in Tripterygium wilfordii Hook F., has a broad spectrum of biological functions, inhibits canonical Wnt/β-catenin signaling by targeting β-catenin. |
PC-44658 |
FH535
PPARγ/δ inhibitor
|
FH535 is a potent, dual PPARγ/δ antagonist that is able to inhibit GRIP1 and β-catenin recruitment, inhibits the Wnt/β-catenin pathway. |
PC-20658 |
Liquidambaric acid
TRAF2 inhibitor
|
Liquidambaric acid (Betulonic acid) ia a natural compound inhibiting oncogenic Wnt/β-catenin signaling in vitro and in vivo, directly targets tumor necrosis factor receptor-associated factor 2 (TRAF2) with Kd of 6.02 uM in MST assays. |