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Cat. No. Product Name Information
PC-61322

CGP049090

β-catenin/LEF1 inhibitor

CGP049090 (Cercosporin) is a small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines.
PC-61321

CCT-031374 hydrobromide

beta-catenin inhibitor

A novel small-molecule Wnt signaling inhibitor that inhibits TCF-dependent transcription with IC50 of 6.1 uM in 7dF3 reporter assay.
PC-61288

Tegatrabetan

beta-catenin inhibitor

Tegatrabetan (BC-2059, BC2059, Tegavivint) is an orally bioavailable β-catenin antagonist that disrupts the binding of β-catenin to TBL1 and promotes β-catenin degradation, attenuates nuclear and cytoplasmic levels of β-catenin.
PC-70120

PRI-724

CBP/beta-catenin inhibitor

PRI-724 (Foscenvivint, OP-724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM.
PC-70092

KYA1797K

Wnt/β-catenin inhibitor

KYA1797K is a derivative of KY1220 with improved inhibitory activity for Wnt/β-catenin signaling.
PC-70091

KY-1220

Wnt/β-catenin inhibitor

KY-1220 is a small molecule destabilizer of both β-catenin and Ras via inhibition of the Wnt/β-catenin pathway (IC50=2.1 uM).
PC-42398

LF3

β-catenin/TCF4 inhibitor

A small-molecule antagonist of the β-catenin/TCF4 interaction with IC50 of 1.65 and 1.82 uM in AlphaScreen and ELISA assay, respectively.
PC-42676

IQ-1

p300/β-catenin inhibitor

A small molecule, specific inhibitor of p300/β-catenin interaction that binds to PR72/130 subunit of PP2A.
PC-42324

PNU-74654

Tcf/β-catenin inhibitor

PNU-74654 (PNU74654) is a potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction binds to β-catenin with Kd of 450 nM.
PC-45815

Triptonide

beta-catenin inhibitor

Triptonide (NSC 165677, PG 492) is a key bioactive small molecule identified in Tripterygium wilfordii Hook F., has a broad spectrum of biological functions, inhibits canonical Wnt/β-catenin signaling by targeting β-catenin.
PC-44658

FH535

PPARγ/δ inhibitor

FH535 is a potent, dual PPARγ/δ antagonist that is able to inhibit GRIP1 and β-catenin recruitment, inhibits the Wnt/β-catenin pathway.
PC-20658

Liquidambaric acid

TRAF2 inhibitor

Liquidambaric acid (Betulonic acid) ia a natural compound inhibiting oncogenic Wnt/β-catenin signaling in vitro and in vivo, directly targets tumor necrosis factor receptor-associated factor 2 (TRAF2) with Kd of 6.02 uM in MST assays.

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