| Cat. No. |
Product Name |
Information |
| PC-28110 |
β-catenin-BCL9 inhibitor 28
β-catenin/BCL9 inhibitor
|
β-catenin-BCL9 inhibitor 28 is a potent and selective inhibitor of β-catenin/BCL9 interaction, shows high-affinity binding to β-catenin with SPR Kd of 82 nM, enhances antigen presentation and activates cDC1 cells. |
| PC-28109 |
ZD-4009
β-catenin/BCL9 inhibitor
|
ZD-4009 is a potent and selective inhibitor of B-cell lymphoma 9 (BCL9), shows high-affinity binding to β-catenin with KD of 44.72 nM, shows antifibrotic efficacy. |
| PC-27045 |
Zolucatetide
TCF/β-catenin inhibitor
|
Zolucatetide (FOG-001, I-66) is a potent β-catenin inhibitor with IC50 of <50 nM, inhibits β-catenin and T-cell factor (TCF) transcription factor PPI, inhibits cell proliferation and induces cell cycle arrest in target cells. |
| PC-20622 |
ICG-001
TCF/beta-catenin inhibitor
|
ICG-001 (ICG001) is a specific small molecule inhibitor of TCF/beta-catenin, antagonizes β-catenin/TCF-mediated transcription with IC50 of 3 uM. |
| PC-20582 |
HI-B1
β-catenin/TCF4 inhibitor
|
HI-B1 is a small molecule inhibitor of β-catenin/TCF4 interaction, directly targets β-catenin and disrupts β-catenin/TCF4 complex formation. |
| PC-20175 |
IMU1003
Wnt/β-catenin inhibitor
|
IMU1003 (IMU-1003) is a small molecule inhibitor of Wnt/β-catenin signaling, decreases β-catenin levels and inhibits target gene expression that promotes cancer cell proliferation. |
| PC-38652 |
PTK7/β-catenin inhibitor 01065
PTK7/β-catenin inhibitor
|
PTK7/β-catenin inhibitor 01065 is a small molecule inhibitor of PTK7/β-catenin interaction (IC50=8.9 uM) targeting the Wnt pathway signaling, induces antiproliferative and antitumor effects in vitro in CRC cells harboring β-catenin or adenomatous polyposis coli (APC) mutations. |
| PC-38567 |
E722-2648
β-catenin/BCL9 inhibitor
|
E722-2648 (Compound C-1) is a novel specific and competitive small molecule β-catenin/BCL9 interaction inhibitor with ITC KD of 1.05 uM and IC50 of 9 uM, blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer. |
| PC-38409 |
Miclxin
MIC60 inhibitor
|
Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM). |
| PC-73231 |
GB1874
Beta-catenin-TCF4 inhibitor
|
GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction. |
| PC-73060 |
RX-5902
P-p68 inhibitor
|
RX-5902 (Supinoxin, RX5902) is a small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68) and attenuates nuclear shuttling of β-catenin. |
| PC-72708 |
ZW4864
β-catenin/BCL9 inhibitor
|
ZW4864 (ZW-4864) is an orally bioavailable small-molecule that binds with β-catenin and selectively disrupts the PPI between BCL9 and β-catenin, while sparing the β-catenin/E-cadherin PPI. |
