| Cat. No. |
Product Name |
Information |
| PC-45427 |
Prexasertib
CHK1 inhibitor
|
Prexasertib (LY2606368, ACR-368) is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM. |
| PC-44037 |
LY2603618
CHK1 inhibitor
|
Rabusertib (LY2603618) is a potent and selective small molecule inhibitor of Chk1 (IC50= 7 nM). |
| PC-42769 |
AZD-7762
Chk1/Chk2 inhibitor
|
AZD-7762 (AZD7762) is a potent and selective inhibitor of Chk1/2 with IC50 of 5 nM. |
| PC-44033 |
CCT241533 hydrochloride
Chk2 inhibitor
|
CCT241533 hydrochloride is a potent and selective ATP-competitive inhibitor of CHK2 with IC50 of 3 nM. |
| PC-44032 |
CCT241533
Chk2 inhibitor
|
CCT241533 is a potent and selective ATP-competitive inhibitor of CHK2 with IC50 of 3 nM. |
| PC-45429 |
CCT244747
CHK1 inhibitor
|
CCT244747 (CCT 244747) is a potent, highly selective, orally active, ATP competitive CHK1 inhibitor with biochemical IC50 of 8 nM. |
| PC-45574 |
CCT245737
CHK1 inhibitor
|
CCT245737 (SRA-737) is a highly potent, selective, ATP-competitive inhibitor of Chk1 with IC50 of 1.3 nM. |
| PC-25459 |
Morusinol
CHK1 degrader
|
Morusinol is a flavonoid isolated from Morus alba root bark, has antiplatelet activity and significantly inhibits arterial thrombosis in vivo,
induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma by CHK1 degradation through the ubiquitin-proteasome pathway. |
| PC-24519 |
LY2880070
CHK1 inhibitor
|
LY2880070 (LY-2880070) is a highly potent, selective and orally active CHK1 inhibitor with IC50 of 0.5 nM. |
| PC-24518 |
BEN-28010
CHK1 inhibitor
|
BEN-28010 is a potent selective, orally bioavailable and brain-penetrant checkpoint kinase 1 (CHK1) inhibitor with IC50 of 4 nM, 450-fold selective over CHK2. |
| PC-21172 |
2OH-BNPP1
BUB1 inhibitor
|
2OH-BNPP1 is a small molecule inhibitor of BUB1 (budding uninhibited by benzimidazoles-1) kinase, abrogates TGFβ signaling. |
