| Cat. No. |
Product Name |
Information |
| PC-22109 |
GSK_WRN3
WRN helicase inhibitor
|
GSK_WRN3 (WRNi, GSK-WRN3) is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 8.6, covalently targets WRN Cys727 residue. |
| PC-22108 |
GSK_WRN2
WRN helicase inhibitor
|
GSK_WRN2 (GSK-WRN2) is a potent and highly selective WRN helicase covalent inhibitor with biochemical pIC50 of 6.5, covalently targets WRN Cys727 residue. |
| PC-21907 |
Hycanthone
APE1 inhibitor
|
Hycanthone is a thioxanthenone DNA intercalator, inhibits RNA synthesis as well as the DNA topoisomerases I and II, inhibits apurinic endonuclease 1 (APE1) incision of depurinated plasmid DNA with IC50 of 80 nM. |
| PC-21245 |
KY386
DHX33 inhibitor
|
KY386 is a potent, selective inhibitor of RNA helicase DHX33 with IC50 of 19 nM. |
| PC-21006 |
H3B-968
WRN inhibitor
|
H3B-968 is a potent, selective and covalent inhibitor of Werner syndrome protein (WRN) helicase activity with IC50 of 41 and 13 nM in ADP-Glo assay DNA unwinding assay, respectively. |
| PC-21005 |
H3B-960
WRN helicase inhibitor
|
H3B-960 is a potent, selective and covalent inhibitor of Werner syndrome protein (WRN) helicase activity with IC50 of 60 nM. |
| PC-20997 |
AOH1996
PCNA inhibitor
|
AOH1996 (AOH-1996) is a small molecule, orally active inhibitor of cancer-associated isoform of proliferating cell nuclear antigen (caPCNA), exerts potent, selective anticancer effects. |
| PC-20677 |
Werner syndrome RecQ helicase-IN-4
WRN inhibitor
|
Werner syndrome RecQ helicase-IN-4 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor with IC50 of 60 nM for WRN ATPase. |
| PC-20676 |
Werner syndrome RecQ helicase-IN-3
WRN inhibitor
|
Werner syndrome RecQ helicase-IN-3 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor with IC50 of 60 nM for WRN ATPase. |
| PC-20675 |
Werner syndrome RecQ helicase-IN-2
WRN inhibitor
|
Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor with IC50 of 100 nM for WRN ATPase. |
| PC-20674 |
HRO761
WRN inhibitor
|
HRO761 (HRO-761) is the first potent and selective, allosteric inhibitor of RecQ DNA helicase WRN with IC50 of 50 nM, shows potent and selective anti-tumor activity in cancers with microsatellite instability. |
| PC-49111 |
SU0448
MTH1 activator
|
SU0448 is a specific, cell-permeable small molecule activator of the DNA repair enzyme Human MutT Homolog 1 (MTH1) with AC50 value of 5.5 uM, inhibits cell viability of HCC1806 cells with IC50 of 36.1 uM. |
