| Cat. No. |
Product Name |
Information |
| PC-22150 |
PF-719
Pyk2 inhibitor
|
PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM). |
| PC-20683 |
BSJ-04-175
FAK inhibitor
|
BSJ-04-175 is a potent, selective focal adhesion kinase (FAK, protein tyrosine kinase 2 or PTK2) inhibitor with biochemical IC50 of 22 nM, 30-fold selectivity over PYK2. |
| PC-20058 |
AMP945
FAK inhibitor
|
Narmafotinib (AMP945, CTX-0294945) is a potent, selective and orally bioavailable Focal Adhesion Kinase (FAK) inhibitor with IC50 of 2.2 nM, >200-fold selectivity over Pyk2. |
| PC-72153 |
BJG-03-025
FAK inhibitor
|
BJG-03-025 is a potent, highly selective FAK tyrosine kinase inhibitor with biochemical IC50 of 20.2 nM. |
| PC-43036 |
Y15
|
FAK inhibitor Y15 is a small molecule inhibitor targeting the main autophosphorylation site of FAK, specifically blocks phosphorylation of Y397-FAK (IC50=1 uM) and total phosphorylation of FAK. |
| PC-42952 |
Defactinib hydrochloride
|
Defactinib (VS-6063,PF-04554878) is a potent, selective and orally active FAK inhibitor, inhibits pFAK (Tyr397) in a dose-dependent manner in cancer cell lines. |
| PC-62799 |
PF-4618433
|
PF-4618433 is a highly potent, dual PYK2/FAK inhibitor, shows robust osteogenic activity in hMSC cultures.. |
| PC-62798 |
Pyk2-IN-25a
|
Pyk2-IN-25a is a highly potent Pyk2 (PTK2B) inhibitor with IC50 of 0.67 nM, dispalys 2-fold weakening potency for FAK (IC50=1.26 nM). |
| PC-70128 |
OXA-11
|
A potent and selective inhibitor of FAK phosphorylation with biochemical IC50 of 1.2 pM (pFAK Y397), cellular IC50 of 1 nM. |
| PC-45578 |
TAS-301
|
An inhibitor of smooth muscle cell migration and proliferation. |
| PC-45629 |
NAMI-A
|
A ruthenium anticancer agent that has a selective effect on lung metastases of solid metastasizing tumors. |
| PC-42602 |
PF-573228
|
A potent, selective, ATP-competitive FAK inhibitor with IC50 of 4 nM. |
