| Cat. No. |
Product Name |
Information |
| PC-60147 |
JTZ-951
HIF-PHD inhibitor
|
Enarodustat (JTZ-951) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2. |
| PC-45660 |
THS-044
HIF2α modulator
|
THS-044 is a low micromolar HIF2α PAS-B binding compound (Kd=2 uM). |
| PC-45555 |
KC7F2
HIF-1α inhibitor
|
KC7F2 is a small molecule HIF-1α translation inhibitor with IC50 of 20 uM. |
| PC-42474 |
PX-478
HIF-1α inhibitor
|
PX-478 is a potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity. |
| PC-45759 |
HIF2α-IN-1
|
A potent HIF-2α inhibitor with IC50 of <500 nM in HIF-2α scintillation proximity assay. . |
| PC-42346 |
Vadadustat
HIF-PHD inhibitor
|
Vadadustat (PG-1016548, AKB-6548) is a novel, potent, orally active HIF prolyl-4-hydroxylase (HIF-PHD) inhibitor with pKi of for PHD1, PHD2, and PHD3, respecitvely. |
| PC-42229 |
SYP-5
HIF-1 inhibitor
|
SYP-5 is a potent HIF-1 inhibitor that inhibits hypoxia-induced upregulation of HIF-1, suppresses tumor cells invasion and angiogenesis. |
| PC-45387 |
Daprodustat
HIF-PHD inhibitor
|
Daprodustat (GSK1278863) is a potent, orally active HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 3.5, 22.2 and 2.2 nM for PHD1, PHD2 and PHD3, respectively. |
| PC-24485 |
HIF-PH inhibitor 13
HIF-PH inhibitor
|
HIF-PH inhibitor 13 is a potent, orally bioavailable hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 0.1 uM (PHD2). |
| PC-24484 |
M1002
HIF-2 agonist
|
M1002 is a small molecule allosteric agonist of hypoxia-inducible factor-2 (HIF-2) with EC50 of 0.44 uM in luciferase reporter gene assays, enhances the affinity of HIF-2α and ARNT for transcriptional activation. |
| PC-24483 |
ZG-2033
HIF-2α agonist
|
ZG-2033 is a potent, selective and orally bioavailable HIF-2α agonist with EC50 of 490 nM, Emax = 349.2%. |
| PC-24421 |
PRLX 93936
HIF-1α inhibitor
|
PRLX 93936 (PRLX-93936) is a potent small molecule inhibitor of HIF-1α transcriptional factor with IC50 of 0.09 uM, shows with broad antitumor activity in vitro. |
