| Cat. No. |
Product Name |
Information |
| PC-23636 |
Takeda-17
PHD inhibitor
|
Takeda-17 (PHD-1 inhibitor 17) is a potent, selective inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) with IC50 of 34 nM. |
| PC-23635 |
JPHM-2-167
PHD inhibitor
|
JPHM-2-167 is a potent, selective prolyl hydroxylase (PHD) inhibitor with IC50 of 1.7, 2.1 and 11 nM for PHD1, PHD2, and PHD3 respectively. |
| PC-23634 |
DDO-3055
PHD inhibitor
|
DDO-3055 is a potent, selective prolyl hydroxylase (PHD) inhibitor with IC50 of 64.2 nM toward PHD2, 29- and 2.6-fold selective over PHD1 and PHD3. |
| PC-23633 |
ISM012-042
HIF-PHD inhibitor
|
ISM012-042 is a potent, orally gut-restricted, selective PHD1 and PHD2 inhibitor with IC50 of 1.9 nM and 2.5 nM for PHD1 hydroxylase and PHD2 hydroxylase, respectively. |
| PC-23246 |
ZG-2305
FIH inhibitor
|
ZG-2305 is a potent, and selective inhibitor of factor inhibiting HIF (FIH) with Ki of 79.6 nM, 38-fold selectivity over HIF prolyl hydroxylase PHD2. |
| PC-22855 |
DS-1093a
HIF-PHD inhibitor
|
DS-1093a is a potent, selective and oral hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with EC50 of 0.49 uM (EPO production in Hep3B cells). |
| PC-22692 |
HIF-PH inhibitor DMOG
HIF-PH inhibitor
|
DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF prolyl hydroxylase (HIF-PH), induces HIF-1α stabilisation and accmulation in vitro and in vivo. |
| PC-22621 |
N-oxalylglycine
2OG oxygenase inhibitor
|
N-oxalylglycine (NOG) is a broad-spectrum 2OG oxygenase inhibitor with IC50 of 0.36 uM, 12.3 uM, 11.1 uM and 0.15 uM for FIH, PHD2, aspartate/asparagine-β-hydroxylase (AspH) and JMJD5, respectively. |
| PC-22620 |
PHD2 inhibitor BNS
2OG oxygenase inhibitor
|
PHD2 inhibitor BNS is a broad-spectrum 2OG oxygenase inhibitor with IC50 of 0.3 uM, 0.11 uM, 3.4 uM and 0.25 uM for FIH, PHD2, aspartate/asparagine-β-hydroxylase (AspH) and JMJD5, respectively. |
| PC-22619 |
ZG-2291
FIH inhibitor
|
ZG-2291 is a highly potent, selective and in vivo active factor inhibiting HIF (FIH) inhibitor with Ki of 65.3 nM, 39-fold selective over PHD2. |
| PC-22355 |
DS44470011
HIF-PHD inhibitor
|
DS44470011 is a potent, selective hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor with IC50 of 1.5 uM for HIF-PHD2, induces erythropoietin (EPO) release in Hep3B cells with EC50 of 8.4 uM. |
| PC-22353 |
PHD inhibitor IOX5
HIF-PHD inhibitor
|
IOX5 is a potent, selective HIF-prolyl hydroxylase (PHD) inhibitor with IC50 of 0.15 uM ((PHD2), does not inhibit other 2OG-dependent oxygenases (JMJD6, FIH, KDM6B etc.). |
