| Cat. No. |
Product Name |
Information |
| PC-22129 |
DS-1-38
EYA1 inhibitor
|
DS-1-38 (EYA1 inhibits DS38) is a small molecule allosteric inhibitor of EYA proteins and sonic hedgehog (SHH) signaling pathway, binds to EYA1 and inhibits EYA1 phosphatase activity. |
| PC-49551 |
Picoberin
AhR agonist
|
Picoberin is a highly potent (low picomolar) inhibitor of purmorphamine- and Sonic Hedgehog (Shh)-induced osteogenesis with IC50 of 3 pM, acts as an AhR agonist and induces the expression of AhR target genes, thereby suppressing osteoblast differentiation. |
| PC-63064 |
Cyclopamine tartrate
|
Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM. |
| PC-62182 |
Robotnikinin
|
Robotnikinin is asmall molecule that binds the extracellular Sonic Hedgehog (Shh) protein (Kd=3.1 uM) and blocks Shh-signaling in cell lines, human primary keratinocytes and synthetic model of human skin. |
| PC-62176 |
AY-9944
|
AY-9944 is a cholesterol biosynthesis inhibitor that targets the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM), attenuates of Smoothened-dependent and -independent Hh signaling. |
