You are here:Home-Inhibitors & Agonists-NF-κB Pathway-IκB kinase (IKK)

Request The Product List ofIκB kinase (IKK) IκB kinase (IKK)

Cat. No. Product Name CAS No. Information



SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM); inhibits FCS-stimulated phosphorylation of p100 in U2OS cells with IC50 of 8.8 uM, inhibits the noncanonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway.



851814-28-3 PIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells; downregulates polyinosine:polycytidylic acid (poly I:C)-stimulated phosphorylation of interferon responsive factor-3 (IRF3), a substrate of TBK1/IKKε; augments β-cell-specific proliferation by increasing cAMP levels and mTOR activity via PDE3, improves glucose control and β-cell mass in the STZ-induced diabetic mouse model.


1186195-62-9 IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively; inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM with IC50 of 1.0, 0.5, 0.3 and 0.3 uM respectively; inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis models.

ACHP hydrochloride

406209-26-5 ACHP hydrochloride is a potent and specific inhibitor for IKK-β with IC50 of 8.5 nM, moderately inhibits IKK-α with IC50 of 250 nM, exhibits good selectivity over other kinases, such as IKK3, Syk and MKK4 (IC50>20 uM); inhibits TNFα-induced RANTES production in A549 cells with IC50 of 40 nM, inhibits NF-κB-dependent reporter gene activation in TNFα -activated HEK293 cells and PMA/calcium ionophore-activated Jurkat T cells; demonstrates in vivo anti-inflammatory assays (1mg/kg, po) in arachidonic acid-induced ear edema model in mice; also inhibits TNF-α-induced HIV-1 replication in latently infected cells with EC50 of 0.56 uM.


960293-88-3 BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK; inhibits TNF-α-dependent IκB degradation and expression of proinflammatory mediators interleukin-6, interleukin-1β, and CXCL1/2 in vivol; partially inhibits the IL-1-stimulated activation of IKKε/TBK1.


1292310-49-6 TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM; inhibits IRF3 nuclear translocation with IC50 of 95 nM, but does not significantly inhibits cell proliferation in some NSCLC, pancreatic, and colorectal cell lines.


1266240-87-2 IKK2-IN-8 is a potent, selective IKK2 inhibitor with IC50 of 6 nM, displays >40-fold selectivity over IKK1 (IC50=230 nM); inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 80 nM.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:
Contact Us