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Cat. No. Product Name CAS No. Information
PC-35736

PIAA

851814-28-3 PIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells; downregulates polyinosine:polycytidylic acid (poly I:C)-stimulated phosphorylation of interferon responsive factor-3 (IRF3), a substrate of TBK1/IKKε; augments β-cell-specific proliferation by increasing cAMP levels and mTOR activity via PDE3, improves glucose control and β-cell mass in the STZ-induced diabetic mouse model.
PC-63330

IKK16

1186195-62-9 IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively; inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM with IC50 of 1.0, 0.5, 0.3 and 0.3 uM respectively; inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis models.
PC-43364

ACHP hydrochloride

406209-26-5 ACHP hydrochloride is a potent and specific inhibitor for IKK-β with IC50 of 8.5 nM, moderately inhibits IKK-α with IC50 of 250 nM, exhibits good selectivity over other kinases, such as IKK3, Syk and MKK4 (IC50>20 uM); inhibits TNFα-induced RANTES production in A549 cells with IC50 of 40 nM, inhibits NF-κB-dependent reporter gene activation in TNFα -activated HEK293 cells and PMA/calcium ionophore-activated Jurkat T cells; demonstrates in vivo anti-inflammatory assays (1mg/kg, po) in arachidonic acid-induced ear edema model in mice; also inhibits TNF-α-induced HIV-1 replication in latently infected cells with EC50 of 0.56 uM.
PC-43329

BI605906

960293-88-3 BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK; inhibits TNF-α-dependent IκB degradation and expression of proinflammatory mediators interleukin-6, interleukin-1β, and CXCL1/2 in vivol; partially inhibits the IL-1-stimulated activation of IKKε/TBK1.
PC-43042

TBK1-IN-1

1292310-49-6 TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM; inhibits IRF3 nuclear translocation with IC50 of 95 nM, but does not significantly inhibits cell proliferation in some NSCLC, pancreatic, and colorectal cell lines.
PC-63117

IKK2-IN-8

1266240-87-2 IKK2-IN-8 is a potent, selective IKK2 inhibitor with IC50 of 6 nM, displays >40-fold selectivity over IKK1 (IC50=230 nM); inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 80 nM.
PC-63116

IKK2-IN-9

1266240-89-4 IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM); inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 0.22 uM; dose-dependently inhibist the TNF-α response in murine model of acute inflammation.

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