| Cat. No. |
Product Name |
Information |
| PC-61091 |
PF-05388169
IRAK4 inhibitor
|
PF-05388169 is a potent, selective IRAK4 inhibitor with IC50 of 0.094 nM, >500-fold selectivity over IRAK1 (IC50=65 nM). |
| PC-60997 |
AS2444697
IRAK4 inhibitor
|
AS2444697 is a potent, selective, orally bioavailable IRAK4 inhibitor (IC50=21 nM), potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1. |
| PC-60980 |
IRAK4-IN-16
IRAK4 inhibitor
|
IRAK4-IN-16 is a potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively. |
| PC-50002 |
Emavusertib
IRAK4 inhibitor
|
Emavusertib (CA4948, AU4948) is a potent, selective and orally active IRAK4 inhibitor with IC50 of 31.7 nM. |
| PC-70009 |
Thymoquinone
IRAK1 inhibitor
|
Thymoquinone is an anticancer phytochemical commonly found in black cumin, exhibits anticancer activity via numerous mechanisms of action, specifically by showing selective antioxidant and oxidant activity. |
| PC-60013 |
AZ1495
IRAK4 inhibitor
|
AZ1495 is a potent, selective IRAK4 inhibitor with IC50 of 51 nM. |
| PC-45740 |
PF-06650833
IRAK4 inhibitor
|
Zimlovisertib (PF-06650833) is a potent and selective IRAK4 inhibitor with IC50 of 0.2 nM. |
| PC-26786 |
UR241-2
IRAK4 inhibitor
|
UR241-2 is a potent and selective IRAK4 inhibitor with IC50 of 1.93 nM in HotSpot Kinase assays, inhibits NF-κβ nuclear translocation and blocks IL-1β–induced IRAK4 phosphorylation. |
| PC-24961 |
Nacresertib
IRAK4 inhibitor
|
Nacresertib is a potent, selctive IRAK4 inhibitor with IC50 of 6.0 nM, >500-fold selective over IRAK1 |
| PC-22315 |
JH-I-25
IRAK4 inhibitor
|
JH-I-25 is a potent, selective and orally bioavailable interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with IC50 of 20 nM. |
| PC-22268 |
BIO-8169
IRAK4 inhibitor
|
BIO-8169 is a highly potent, selective, brain-penetrant and oral bioavailable IRAK4 inhibitor with IC50 of 0.23 nM, potently inhibits R848 stimulated IL-1β production with IC50 of 246 nM in HWB assays. |
| PC-22241 |
DW18134
IRAK4 inhibitor
|
DW18134 is a potent, selective IRAK4 kinase inhibitor with IC50 of 11.2 nM, inhibits the IRAK4-induced activation of NF-κB signaling. |
