| Cat. No. |
Product Name |
Information |
| PC-20532 |
IDH2 R140Q inhibitor CP-17
IDH2 R140Q inhibitor
|
IDH2 R140Q inhibitor CP-17 is a potent, selective inhibitor of IDH2 R140Q mutation with IC50 of 40.75 nM, 50-fold selectivity over wild-type IDH1/2. |
| PC-35209 |
BRD2879
|
BRD2879 (BRD-2879) is a potent, selective inhibitor of IDH1-R132H mutant with IC50 of 50 nM, inhibits cell-based production of R-2HG with EC50 of 0.3 uM. |
| PC-35208 |
mutant IDH1 inhibitor VVS
|
mutant IDH1 inhibitor VVS is a potent, selective mutant IDH1 inhibitor with nanomolar potency against both IDH1 R132H and IDH1 R132C, efficiently suppresses the cell-based production of D-2-HG in an HEK293 mutant embryonic kidney cell line.. |
| PC-35207 |
SYC-435
|
SYC-435 (SYC435) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C. |
| PC-35206 |
AGI-14100
|
AGI-14100 (AGI14100) is a novel potent and selective, orally available IDH1 mutant inhibitor. |
| PC-35142 |
MRK-A
|
MRK-A is a potent, highly selective, brain penetrant inhibitor of mutant IDH1 with IC50 of 5 nM, displays a 10,000-fold mutant to wildtype selectivity ratio. |
| PC-35141 |
HMS-101
|
HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively). |
| PC-43052 |
Mutant IDH1-IN-1
|
Mutant IDH1-IN-1 is a potent, mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively. |
| PC-62686 |
ML309
|
ML 309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM. |
| PC-62685 |
ML309 hydrochloride
|
ML 309 is a potent, selective mutant IDH1 R132H inhibitor with IC50 of 96 nM. |
| PC-70088 |
GSK-321
|
GSK-321 is a highly potent, selective inhibitor of mutant IDH1 with IC50s of 4.6/3.8/2.9 nM for R132H/R132C/R132G respectively. |
| PC-45413 |
AGI-5198
|
A potent, selective mutant IDH1 inhibitor with IC50 of 70 nM and 160 nM for R132H-IDH1 and R132C-IDH1, respectively. |
