Cat. No. |
Product Name |
Information |
PC-21238 |
DS-3032 tosylate hydrate
MDM2-p53 inhibitor
|
Milademetan (DS-3032b) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity. |
PC-20688 |
MMRi71
MDM2-MDM4 E3 ligase inhibitor
|
MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells. |
PC-20687 |
MMRi67
MDM2-MDM4 E3 ligase inhibitor
|
MMRi67 is a potent E3 ligase inhibitor of the MDM2-MDM4 E3 complex, inhibits RING-RING interaction of MDM4 and MDM2B with Kd of 896 nM. |
PC-20668 |
BI-907828
MDM2 inhibitor
|
BI 907828 ( Brigimadlin) is an orally available inhibitor of murine double minute 2 (MDM2) with potential antineoplastic activity, BI 907828 binds to MDM2 protein and prevents its binding to p53. |
PC-20010 |
J012-3168
RPL11-MDM2 inhibitor
|
RPL11-MDM2 inhibitor S9 (J012-3168) is a small-molecule RPL11 mimetic and potential inhibitor of RPL11-MDM2 interaction, directly binds MDM2 and induces p53 stabilization and activation. |
PC-49577 |
K-181
Mdmx-p53 inhibitor
|
K-181 is a specific small-molecule Protein-Protein Interaction (PPI) inhibitor of Mdmx-p53 interaction, exhibits neuroprotective effects on ischemic stroke by disrupting Mdmx-p53 interaction and inhibiting HDAC6 activity. |
PC-49512 |
GY1-22
DNAJA1-mutp53R175H inhibitor
|
GY1-22 is a small molecule inhibitor against DNAJA1-mutP53R175H interacting pocket, reduces mutp53 protein expression in colon cancer cell line with p53R175H mutation. |
PC-49493 |
UC2288
p21 inhibitor
|
UC2288 is a small molecule p21 inhibitor, attenuates p21 protein abundance at 10 µM, independently of p53 activity and at the level of transcription or post-transcription. |
PC-38473 |
Inauhzin
p53 activator
|
Inauhzin (INZ) is a small molecule SIRT1 inhibitor that effectively reactivates p53, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. |
PC-35309 |
MB710
|
MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro.. |
PC-35308 |
MB725
|
MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM). |
PC-42949 |
YH239-EE
|
YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4. |