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Cat. No. Product Name Information
PC-21238

DS-3032 tosylate hydrate

MDM2-p53 inhibitor

Milademetan (DS-3032b) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.
PC-20688

MMRi71

MDM2-MDM4 E3 ligase inhibitor

MMRi71 is a small molecule inhibitor of the E3 ligase activity of MDM2-MDM4, and an inducer of MDM4 and FTH1 dual protein degradation and p53-independent apoptosis in leukemia cells.
PC-20687

MMRi67

MDM2-MDM4 E3 ligase inhibitor

MMRi67 is a potent E3 ligase inhibitor of the MDM2-MDM4 E3 complex, inhibits RING-RING interaction of MDM4 and MDM2B with Kd of 896 nM.
PC-20668

BI-907828

MDM2 inhibitor

BI 907828 ( Brigimadlin) is an orally available inhibitor of murine double minute 2 (MDM2) with potential antineoplastic activity, BI 907828 binds to MDM2 protein and prevents its binding to p53.
PC-20010

J012-3168

RPL11-MDM2 inhibitor

RPL11-MDM2 inhibitor S9 (J012-3168) is a small-molecule RPL11 mimetic and potential inhibitor of RPL11-MDM2 interaction, directly binds MDM2 and induces p53 stabilization and activation.
PC-49577

K-181

Mdmx-p53 inhibitor

K-181 is a specific small-molecule Protein-Protein Interaction (PPI) inhibitor of Mdmx-p53 interaction, exhibits neuroprotective effects on ischemic stroke by disrupting Mdmx-p53 interaction and inhibiting HDAC6 activity.
PC-49512

GY1-22

DNAJA1-mutp53R175H inhibitor

GY1-22 is a small molecule inhibitor against DNAJA1-mutP53R175H interacting pocket, reduces mutp53 protein expression in colon cancer cell line with p53R175H mutation.
PC-49493

UC2288

p21 inhibitor

UC2288 is a small molecule p21 inhibitor, attenuates p21 protein abundance at 10 µM, independently of p53 activity and at the level of transcription or post-transcription.
PC-38473

Inauhzin

p53 activator

Inauhzin (INZ) is a small molecule SIRT1 inhibitor that effectively reactivates p53, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.
PC-35309

MB710

MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket and stabilizes p53-Y220C in vitro..
PC-35308

MB725

MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM).
PC-42949

YH239-EE

YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4.

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